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Update for July 26
*Based on 50 mg pill split in half
This month, Costco shoppers can expect to pay exactly the same as last month, $56.40 for a 20 milligram pill for brand-name Cialis. If you only need 10 milligrams, you can use a pill splitter to divide the tablet, reducing the cost to $28.20 per dose.
Across all retailers, the average price of a Cialis 100 milligram tablet is currently $59.31, putting Costco on the lower end of the range.
Tadalafil Prices at Costco
However, you don’t need to go with the brand name. Tadalafil, the generic version of Cialis, offers the same active ingredient at a more affordable price.
Generic tadalafil at Costco costs $1.80 per 20 milligram pill, again just a few cents more than last month. This works out to 90 cents for half a tablet.
On average, tadalafil at 20 milligrams is $6.82 across all retailers, so Costco is beating most of the market.
What to Know About Cialis
Before you take Cialis or its generic equivalent, tadalafil, you should know what you’re putting in your body and its function.
How Cialis Works
Cialis is part of a class of drugs called phosphodiesterase type 5 (PDE5) inhibitors. These medications work by relaxing blood vessels in the body, which allows blood to flow more freely, including into the penis.
For people who are managing erectile dysfunction, this increased blood flow makes it easier to get an erection and to keep it longer.
Who Can Take Cialis
Cialis and tadalafil are FDA-approved only for men 18 and older with erectile dysfunction. Cialis has not been extensively studied for anyone who doesn’t fall into that group, so taking it when you don’t have erectile dysfunction may be dangerous.
Cialis Side Effects
Like any prescription, Cialis can potentially have side effects, and drugs in the same class tend to share side effects. For PDE5 inhibitors, the most common side effects include headaches, nasal congestion, and facial flushing.
These effects can happen because medications in this class impact blood flow throughout the entire body, not just in one specific area. However, different formulations can have different effects; men who experience side effects with Viagra may have lesser or no side effects with Cialis.
A rare but dangerous side effect is priapism, which is an erection that lasts four or more hours, or loss of vision. If you’re experiencing any of these, seek medical help right away. As Cialis can last for up to 36 hours, you should monitor for priapism closely.
Cialis Drug Interactions
Cialis can also interact with other medications. Drugs that affect your liver enzymes may speed up or slow down how your body processes Cialis, and drugs that affect your blood pressure are of particular concern.
There may be other concerns, or benefits. Cialis may be helpful for men dealing with ED as a side effect from antidepressant use, for example.
Before filling any PDE5 inhibitor prescription, make sure to talk to your doctor about all the medications you’re taking, especially if you’re using nitrates like nitroglycerin. Combining nitrates with Cialis can cause a sudden and dangerous drop in blood pressure.
Cialis vs. Tadalafil: What’s the Difference?
Cialis uses the active ingredient tadalafil, which was approved by the FDA in 2003. The generic version became available in 2018.
Brand-name medication and generic medication have the same active ingredients but can have different dyes, fillers, and other ingredients.
Pros and Cons of Choosing Tadalafil (Generic Cialis)
Pros
Price. Generic tadalafil is substantially cheaper than brand-name Cialis. Few people notice the difference between brand-name and generic medications because the active ingredients are exactly the same. So if you’re worried about affording your ED medication, generics are the way to go.
Cons
Brand loyalty. Cialis has been on the market for much longer, and while generic drugs are perfectly safe and have to meet the same quality standards, some men simply feel more comfortable with the formulation that’s been on the market the longest.
Allergy Considerations
Formulation can be key for men concerned about allergies. One formulation may be fine, while another may cause a problem. While the ingredients in pills are inert, except for the active ingredient, and allergic reactions to them are rare, they aren’t unheard of.
At eDrugstore, we offer several options, so you can choose the ED treatment that fits your life and your needs.
Cialis Not Right for You? We Carry Alternatives!
Cialis and tadalafil are just one of a suite of options for treating your ED with PDE5 inhibitors.
Other medication options include:
- Viagra. The original PDE5 inhibitor, Viagra is still widely available in two doses
- Sildenafil. Also called “generic Viagra,” sildenafil has the same active ingredient.
- Vardenafil. Formerly known as Levitra, vardenafil notably can take effect in as little as 15 minutes.
- Stendra. Stendra is a newer medication that’s relatively fast-acting, at 15 to 30 minutes for effects to begin to be felt, and lasts for up to 6 hours. It also has a lower incidence of side effects, making it a good option for people who are sensitive to PDE5 inhibitors.
Ordering Cialis Online May Be the Best Deal
Costco has great prices, but it’s still at the mercy of supply chains and ever-more-complicated markets. Prices today aren’t guaranteed to be the price you pay tomorrow, no matter how dedicated the Costco team is to getting you the best price.
Why Buy Cialis Online with eDrugstore?

eDrugstore is based in Tempe, Arizona, and has been offering safe, legal, convenient, and private prescription services for more than thirty years. Our team of U.S.-licensed healthcare providers will help you find the right ED medication for your needs and budget.
Here’s what you get when you shop at eDrugstore.
Convenience
Ordering from eDrugstore is built to be fast, easy, and flexible. Whether you find the pharmacy embarrassing or just hate the lines, buying online means your medication is shipped to your doorstep, with no small talk or awkwardness.
Privacy and Discretion
If you already have a prescription, we can fill it for you via fax, email, or direct upload, and you’re done. If you’re still considering ED medication, reach out for a consultation with one of our licensed U.S. physicians to learn about your choices and what your path towards a better sex life can be.
If you decide to go with ED medication, it’ll come to your door in generic packaging, protecting your privacy.
No Subscriptions
While other online pharmacies lock you into monthly subscriptions, when you shop with eDrugstore, you buy only what you need, when you need it. You’ll never need to worry about getting automatic charges you weren’t expecting.
Discounts and Savings
We frequently offer discounts on Cialis and other erectile dysfunction medications of up to 75%. Our complimentary physician consultation also means you save on copays, as well as gas driving to the doctor’s office and the pharmacy, as we offer free delivery.
If you’re ordering for the first time, we’ll even send you a pill splitter to help you get the right dose.
Ready to place your order? Check out this month’s discounts and order from eDrugstore with confidence.
Disclaimer: This article provides general information about health and related topics but is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.

Elizabeth Nichols is an experienced and flexible author with extensive experience in both popular media and academic publishing. She specializes in health, medical and travel writing.