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Highlights
- Cialis is an erectile dysfunction drug that works on the same principle as Viagra.
- The active ingredient in Cialis is tadalafil — also the name of its generic version.
- Cialis is available in both as-needed and low-dose daily versions.
- Cialis is the longest-lasting FDA-approved erectile dysfunction drug.
- You can buy Cialis online at eDrugstore and restore the strength of your erections.
Michael DiLeo, MD, has over 30 years of experience in clinical and academic medicine. Through medical school, residency, and private practice, he has functioned as both a specialist and a primary care practitioner. He has twice served as chief of staff of a large regional hospital. He is a published author on women's health for McGraw-Hill. Learn More
If you are looking for an erectile dysfunction drug that enables you to achieve longer-lasting erections than Viagra, Cialis may be your answer. What is Cialis, and how does it achieve its long erection-promoting effects?
What Is Cialis?
Cialis (generic name tadalafil) is a prescription drug that is used to treat erectile dysfunction (ED) in men. It is also used to treat a condition called benign prostatic hyperplasia (BPH), or enlargement of the prostate gland. It may be taken on an as-needed basis or as daily therapy for BPH, ED, or both.
Cialis tablets come in doses of 2.5, 5, 10, and 20 milligrams and are almond-shaped, yellow, and film-coated. Cialis is marketed worldwide by a joint venture of Eli Lilly and ICOS Corporation called Lilly ICOS, LLC.
Cialis was given approval by the U.S. Food and Drug Administration in November 2003. It was the third prescription drug for erectile dysfunction to come onto the market, after Viagra and Levitra (now available only as the generic vardenafil), Cialis can be effective for up to 36 hours, unlike Viagra and vardenafil. Cialis was nicknamed “the weekend pill” due to its prolonged effectiveness.
How Does Cialis Work?
The active substance in Cialis (and the generic name of the drug) is tadalafil. Like all drugs in its class, tadalafil works by inhibiting a substance called PDE-5. However, Cialis is distinctive in that it has a half-life of over 17 hours, compared to four to five hours for Viagra.
During sexual stimulation, the arteries of the penis relax. The response is caused by the release of nitric oxide from endothelial cells and nerve endings. This stimulates the synthesis of a substance called cGMP in smooth muscle cells, which causes the smooth muscle to relax and blood flow to increase.
When PDE-5 is inhibited by an erectile dysfunction drug, nitric oxide is released, cGMP is created, and in the presence of sexual stimulation, an erection results.
Interestingly, PDE-5 is also present in smooth muscle within the lungs, and Cialis has also been approved for the treatment of pulmonary hypertension, a condition that usually results from a type of heart failure.
Side Effects and Drug Interactions with Cialis
Over 8 million men worldwide have taken Cialis, and the most common reported side effects are:
- Headache
- Back pain
- Indigestion
- Facial flushing
- Muscle ache
- Stuffy/runny nose
The side effects have to do with PDE-5 causing dilation of blood vessels. Most of them are mild, however, and usually subside after a few hours. Muscular and back pain tends to occur 12 to 24 hours after taking Cialis, and it usually subsides after 48 hours.
In very rare cases, PDE-5 inhibitors can cause visual impairment. However, most of the patients reporting this side effect had underlying risk factors that predisposed them to the problem.
In 2007, the FDA started requiring labeling on all PDE-5 inhibitors to warn of the rare possibility of a sudden loss of hearing following the use of these drugs.
Men who take organic nitrates should not take them for at least 48 hours after taking Cialis. Recreational drugs, like amyl nitrite, increase the risk of severe hypotension (low blood pressure) when taken within 48 hours of taking Cialis.
Men who take nitrates for chest pain should seek medical attention if they experience angina within 48 hours of taking Cialis; in an emergency medical situation, medical responders should be notified if Cialis was taken within the previous 48 hours.
Cialis Dosage Information
The recommended starting dose for Cialis in most men is 10 milligrams, which is taken as needed before sexual activity. It should not be taken more than once in 24 hours. Depending on efficacy and the patient’s tolerance, the dose may be increased to 20 milligrams or reduced to 5 milligrams.
Cialis is also available as a daily ED treatment at lower doses (2.5 or 5 milligrams ) for convenience.
Cialis vs Viagra vs vardenafil
| How Quickly It Acts | How Long It Lasts | |
| Viagra | 30-60 minutes | 4 hours |
| Cialis | 30 minutes | Up to 36 hours |
| Vardenafil | 60 minutes | 4-5 hours |
| Stendra | 15 minutes for 100 and 200-milligram pills. 30 minutes for 50-milligram doses | 6 hours |
Cialis remains effective far longer than other ED drugs, allowing for greater sexual spontaneity
Cialis, vardenafil, and Viagra all work similarly, though there are subtle differences among the three medications. Viagra and vardenafil take effect in about half an hour. The effects of vardenafil last for around five hours, while Viagra lasts for about four hours. Cialis works within about 15 minutes, and the effects last up to 36 hours.
All three drugs are PDE-5 inhibitors, but they also affect other PDE enzymes. For example, Viagra and vardenafil inhibit PDE-6, which is found in the eye, more than Cialis does. Some users of Viagra report seeing a bluish cast and experiencing greater light sensitivity.
Viagra and vardenafil also inhibit PDE-1, found in the heart, brain, and vascular smooth muscle, more than Cialis does. This results in flushing and rapid heart rate more often in men who take Viagra and vardenafil than in men taking Cialis.
However, Cialis inhibits PDE-11 more than vardenafil and Viagra do. PDE-11 is found in skeletal muscles, the liver, the kidney, the pituitary gland, the prostate, and the testes. The bodily effects of PDE-11 inhibition are not fully known at this time.
Who Should Not Take Cialis?
Men who have had a stroke, heart attack, or life-threatening heart arrhythmia (irregular heart rate) within six months should not take Cialis. Men with high or low blood pressure that is uncontrolled should avoid Cialis, as should men who experience chest pain during sexual activity.
Which ED Medication Is Right for Me?
Patients who have tried Viagra report that side effects with Cialis are less bothersome and that the long-lasting effectiveness allows them to have better rapport and a more spontaneous reaction to their partners.
Many men report that they prefer the milder, longer-lasting effect of Cialis over the more noticeable, shorter-duration effects of Viagra.
However, some men report that they prefer the stronger response that is achieved with Viagra or vardenafil.
Vardenafil is a newer erectile dysfunction drug that was formerly available under the brand name Levitra but is now available only as a generic. Vardenafil also works by stimulating blood flow to the penis. However, because it’s a more selective PDE-5 inhibitor, it causes fewer side effects than sildenafil and tadalafil-based medications like Viagra and Cialis.
Stendra (generic name avanafil) is another highly selective ED drug that causes fewer side effects. Stendra starts to act within 15 minutes, allowing ED sufferers to achieve an erection almost on the spot.
For most men, the choice of an ED drug is a personal preference. Men who can safely take one drug can usually take another safely and gauge their reaction to choose which is best for their particular situation.
Cialis FAQ
Is Cialis Safe to Use with Other Medications?
Cialis is safe, but it can interact with some other medications and foods. Some of these medications and foods are:
- Other PDE-5 inhibitors
- Alpha-blockers
- Nitrates
- Blood pressure medications
- Protease inhibitors
- Anti-infective medications
- Grapefruit
Because of individual differences, allergies, and tolerances, no drug interaction list can be considered complete. If you notice any unusual effects after taking Cialis, talk to a medical provider.
Can I Drink Alcohol While Taking Cialis?
Moderate drinking while on Cialis is generally safe. Drinking too much alcohol can cause dangerously low blood pressure, and symptoms like chest discomfort and dizziness.
How Often Can I Take Cialis?
A 20 milligram Cialis tablet is the maximum daily dose of the medication. Don’t take more than that under any circumstances. Since Cialis’ effects last for 36 hours, there’s no reason to take a 20 milligram tablet daily.
How Should I Take Cialis?
Cialis is an oral medication. You can take it with or without food before you engage in sexual activity.
Can Cialis be Used for Recreational Purposes?
For many, sexual performance enhancement is the definition of the recreational use of a drug. Long-term recreational Cialis is not recommended; it can lead to low erectile confidence, leading to erectile dysfunction even in men who don’t normally suffer from it.
How to Buy Cialis Online
Cialis is a prescription drug. Men who want to order Cialis online should look for online facilitators — like eDrugstore — who contract with U.S.-licensed pharmacists and physicians to safely dispense the drug.
Never buy any prescription drug, including Cialis, from a website that offers them at unusually low prices or that claim to sell “herbal” versions. The “medication” you receive may contain little or no active ingredient and could be contaminated with other, potentially harmful, substances that aren’t disclosed on the label.
At eDrugstore, we carry legitimate, FDA-approved medications — both brand-name Cialis and the generic tadalafil — in both 20 milligram single-dose and 5 milligram daily variants. The effects of tadalafil are the same as those of brand-name Cialis.
Buy With Confidence
If you’re interested in trying Cialis or tadalafil — the generic version of Cialis — call 800- 467-0297 to speak with a pharmacist who will answer your questions. Or browse our medication guide to learn more about Cialis and the other lifestyle medications we carry. We ship quickly, discreetly, and at no extra charge.
Frequently Asked Questions
How does Cialis for daily use help erectile dysfunction cure?
Cialis for daily use, also known as Cialis tadalafil, helps treat erectile dysfunction (ED) by improving blood flow to the penis.
- It works by inhibiting the enzyme PDE5, which helps relax the blood vessels and increase blood flow, promoting sustained and long-lasting erections.
- Daily use of Cialis provides consistent levels of the medication in the body, offering spontaneous erections without the need to plan ahead, improving overall sexual performance and satisfaction.
- While Cialis does not “cure” ED, it is a highly effective treatment option for managing the condition.
Are there any other options for erectile dysfunction?
Yes, besides Cialis tadalafil, other options for erectile dysfunction treatment include:
- Viagra (sildenafil) – Helps improve blood flow by enhancing nitric oxide levels.
- Levitra (vardenafil) – Similar to Viagra, but works slightly differently and may suit some men better.
- Alprostadil (penile injections or suppositories) – Directly stimulates blood flow to the penis for erection.
- Penile implants – A surgical option for severe cases of ED.
- Lifestyle changes such as weight loss, exercise, reducing alcohol, and managing stress also contribute to improving ED.
Can I buy Cialis tadalafil pills online?
Yes, you can buy Cialis tadalafil pills online from reputable online pharmacies like eDrugstore. Ensure you are purchasing from a licensed and trustworthy source to guarantee the authenticity of the medication.
- Buying online offers convenience and discretion, but be cautious of counterfeit products and consult a healthcare provider before purchasing.
- A prescription may be required in some regions, so check the regulations in your country.
What are the benefits of taking Cialis daily?
Taking Cialis daily offers several benefits:
- Spontaneity – Unlike as-needed use, daily Cialis allows for more flexible, spontaneous sexual activity without the need to plan ahead.
- Consistency – The medication builds up in your system, ensuring continuous efficacy over time.
- Improved long-term performance – Daily use may enhance overall satisfaction and performance, reducing anxiety related to ED.
- Reduced need for dosage adjustments – Regular use eliminates the need for on-demand planning, providing a reliable solution for ongoing ED management.
Can I buy Cialis tadalafil without a prescription?
In some regions, Cialis tadalafil may be available for purchase without a prescription, but this varies by country and local regulations.
- In many countries, a prescription is required to ensure safety and appropriate use.
- Buying Cialis without a prescription could lead to risks, including the purchase of counterfeit or substandard products.
- It is always recommended to consult with a healthcare provider before starting any ED medication.
James West is a seasoned health and wellness writer with a focus on topics related to physiology, sleep, and men’s health. He has contributed articles on a range of subjects, from erectile dysfunction treatments and sleep aids to hair loss, providing well-researched insights to help readers make informed health decisions.