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What comes to your mind when someone mentions the word “testosterone”? You probably picture a muscular, tough guy like Arnold Schwarzenegger. A man, in any case.
We all know testosterone as a symbol of masculinity. What most of us don’t realize, is that the same hormone can help improve sexual desire in…women.
Two new drugs for women’s low libido
A Dutch company called Emotional Brain has been working on two new drugs for female sexual interest/arousal disorder (FSIAD), commonly known as low desire. Their innovative approach takes into account women’s individual needs.
Both drugs will have testosterone as an active ingredient. Lybrido will also contain sildenafil (yes, the same chemical found in male Viagra). Lybridos will have buspirone (a serotonin receptor antagonist) as an added ingredient.
Testosterone boosts women’s sexuality too
What’s the role of the “male hormone” testosterone in women’s sexuality? What we need to understand first is that testosterone is not only found in males. Women’s bodies also produce it, in lower amounts. The average levels of the hormone in men are 7-8 times higher than in women.
A “Lancet”-published review of 46 studies proved that testosterone significantly increased sexual function, including frequency and pleasure in women. It also helped reduce distress related to intimacy.
Despite very promising results, one concern remains. Long-term side-effects of testosterone therapy on women are not known. New drugs, developed by Emotional Brain will offer a workaround of sorts. Women will need to take them on demand, a few hours before planned intercourse. This will eliminate the need for daily testosterone therapy.
Results of Lybrido and Lybridos tests so far
First tests of the new drugs have brought positive results, although the studied group of women was quite small. Fifty-six participants – both pre- and postmenopausal – with diagnosed low desire participated in a series of tests.
Every woman did a 4-week course of pills (placebo, testosterone + sildenafil, and testosterone + buspirone). During the study, a series of tests and questionnaires was conducted to check if the participants’ desire and sexual satisfaction changed.
The results confirmed the initial theory of researchers. Women with low sensitivity to sexual stimuli reacted better to the testosterone and sildenafil combo. Women with more sexual inhibition showed better results with the testosterone plus buspirone combination. The results so far have not been clinically significant.
It is also not clear how doctors are supposed to diagnose potential patients into the right categories. Emotional Brain has announced the choice between Lybrido and Lybridos will be based on women’s genetic markers. First studies on how this new approach to diagnostics could look like have been published recently.
Women’s desire is more complex
What do these results tell us about the nature of women’s desire? It looks like female sexual dysfunction is much more difficult to treat with medication. There may never be a “female Viagra” because female sexual response is much more than internal hydraulics.
According to official medical definitions of female sexual interest/arousal disorder, the dysfunction can be recognized by a mix of at least three symptoms such as:
- lack of sexual activity
- lack of erotic thoughts or fantasies
- woman not proposing sex and not responding to the partner’s attempts to initiate
- lack or little pleasure during intimacy
- lack of arousal in contact with erotic cues
- lack or little sensation during sexual activity.
Erectile dysfunction treatment for men focuses on improving blood flow to the penis. It’s a much simpler mechanism.
The drugs developed for women focus on increasing sexual responsiveness or lowering inhibitions such as shame. Scientists suggest that for best results in treating low desire in women, a combination of medication and sexual therapy should be used.
When will the drugs hit the market?
The road to market approval of Lybrido and Lybridos is still long. Emotional Brain’s representative told The Los Angeles Times that the company expects to submit them for FDA approval in 2023. It’s possible the drugs will first become available in Europe.
When dealing with sexual problems, it’s important to remember they are often a combination of issues affecting both partners. For example, a woman’s lack of interest in sex may trigger erectile dysfunction in her male partner.
While women’s treatments are fairly new, ED is easy and safe to treat for most men, using pills such as Viagra. To learn more about ED treatment options, we encourage you to visit our website here.
Anka Grzywacz is a sexologist, reproductive health expert and Certified Sex Coach™. In her online practice she helps busy women and couples solve their intimate problems.