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Sildenafil, the active ingredient in Viagra, might prove to be a useful weapon in the fight against the pulmonary effects of COVID-19. The drug’s ability to stimulate nitric oxide could be the key to its possible success.
Sildenafil, the active ingredient in Viagra, was approved by the U.S. Food and Drug Administration (FDA) nearly 15 years ago for the treatment of pulmonary arterial hypertension (PAH), a form of high blood pressure that targets the lungs. With that in mind, it’s not really surprising that doctors are studying the drug as a potential treatment for the respiratory symptoms of COVID-19.
This article provides background on Sildenafil, how it works to treat ED and lung issues, and how it is being tested in the fight against COVID-19.
History Behind Sildenafil
Sildenafil’s unique effect on the body’s natural supplies of nitric oxide was first discovered by Pfizer research scientists working at a laboratory in England during the early 1990s. Sildenafil was first considered as a novel new treatment for angina pectoris, but early testing yielded less than promising results.
However, a surprising side effect among male members being treated with Sildenafil showed that the drug did seem to significantly improve their ability to get and keep an erection. In fact, some study participants who had been suffering from ED suddenly found that they were able to get an erection.
Pfizer researchers quickly abandoned their pursuit of Sildenafil as a treatment for angina and turned their attention to the drug’s ability to improve erectile function. The rest is history- the drug that emerged from that early study, Viagra, went on to revolutionize the treatment of ED.
How Sildenafil Works
The secret to Sildenafil’s effectiveness against both erectile dysfunction (ED) and high blood pressure is its ability to enlist the body’s natural stores of nitric oxide into its efforts to expand blood vessels. Nitric oxide, produced by nearly every cell in the human body, is a natural vasodilator, meaning that it dilates blood vessels, thereby improving blood flow.
How it Works for ED:
- Helps expand blood vessels that supply the penis, enabling men to get and maintain an erection that’s firm enough for sex.
How it Works for PAH:
- Triggers nitric oxide to dilate the arteries that serve the lungs, thus increasing their ability to deliver oxygen-rich blood to those pulmonary organs.
Sildenafil and COVID-19
Unfortunately, COVID-19 is taking a devastating toll on people across the globe. As a result, researchers are working overtime to find potential treatments before more lives are lost. Researchers in China are actually testing the effectiveness of Viagra in treating breathing issues in patients not yet on ventilators.
Could Sildenafil’s ability to improve blood flow to the lungs help save the lives of COVID-19 patients who otherwise would eventually succumb to the acute respiratory distress syndrome that often characterizes the disease’s end-stage? Only time will tell.
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