Man with a red rash on his side.

Prices of Acyclovir at Major Pharmacies: Updated August 2019

Acyclovir, a powerful antiviral medication, can reduce the number of outbreaks of cold sores, genital herpes, and other lesions caused by herpes simplex viruses 1 and 2. Check our price guide to find your best deal for this medication.

Acyclovir, a prescription antiviral agent and the generic equivalent of Zovirax and Sitavig, is designed to relieve the discomfort of cold sores, shingles, chicken pox, and genital herpes. Although it isn’t a cure for these infections, caused by herpes simplex viruses 1 and 2, it can significantly reduce the incidence and severity of outbreaks.

Check Not Only the Price

Our price guide offers a quick summary of currently posted prices at major U.S. pharmacies — both brick-and-mortar and online. Use the guide to find the deal that’s best to you. But in deciding where to buy, remember to take into consideration all that you’re getting for your money. Some online pharmacies offer low-cost or complimentary services that can save you time and money you might otherwise spend in obtaining the same drugs at a conventional pharmacy.

  • CVS, $6.26 for a 400-milligram acyclovir tablet
  • Walgreens, $6.49
  • Walmart, $5.23
  • Rite Aid, $6.49
  • Kroger, $6.73
  • Target (owned by CVS), $6.26
  • Publix, $0.86
  • Costco, $6.50
  • Meijer, $6.50
  • Fred’s, $6.50
  • Hy-Vee, $6.50
  • Medicine Shoppe International, $8.00
  • Winn-Dixie, $0.56
  • Stop & Shop, $6.50
  • Giant Food Stores, $6.50
  • eDrugstore (online), $2.09

Pricing data is summarized in the following chart:

What the Price Guide Reveals

The pharmacy department at Winn-Dixie, a supermarket chain found primarily in the Southeastern United States, has the lowest price — $0.56 per 400-milligram tablet — among conventional pharmacies. The next lowest price — $0.86 — in this group is at Publix, another supermarket chain confined largely to the Southeast. Walmart, at $5.23 per 400-milligram tablet, has the next lowest price in this group.

eDrugstore offers acyclovir online, selling it for only $2.09 per 400-milligram tablet, far lower than most of the brick-and-mortar pharmacies.

How to Take Acyclovir

As previously noted, acyclovir won’t cure the outbreaks caused by the herpes simplex viruses, but it does sharply reduce the number of outbreaks and the severity of symptoms. The oral medication is to be taken with or without food two to five times a day as directed by your physician. It should be taken at the earliest sign of a pending outbreak.

The side effects most commonly associated with acyclovir include diarrhea, headache, malaise, nausea, stomach pain, and vomiting. These generally disappear after you’ve been on the drug awhile, but if they persist contact your doctor.

Stay Abreast of Latest Prices

This price guide to acyclovir is among the first in a series that will appear regularly in this blog. To stay on top of the latest price trends for acyclovir and a number of other lifestyle medications, including erectile dysfunction drugs, follow the eDrugstore blog on a regular basis.

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Acyclovir is just one of the antiviral agents available from, a longtime online facilitator based in Tempe, Arizona. Others include Valtrex and its generic equivalent, valacyclovir, as well as Denavir. To order these medications, you will need a prescription. If you have one already, you can fax it or scan and email it to eDrugstore along with your order. If not, eDrugstore can set up a complimentary online consultation with a licensed U.S. physician who can authorize a prescription if appropriate. To learn more, visit eDrugstore’s Sexual Health page.

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