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Viagra. We’ve all seen the commercial on television, and the full-page advertisements in magazines. The brand has even become a part of pop culture, whether it is a punch line in a comedy bit or a weapon in a crime drama.
Viagra really isn’t a joke, though, and the effect that this tiny blue pill has had on the world cannot be denied. For men suffering from erectile dysfunction, whether as a result of illness or age, Viagra has given them the ability to function normally, boosting confidence and improving relationship around the world.
What exactly is Viagra, you may ask? How does it work? How much should I take? And what about side effects? Let’s take a look at this remarkable medication and how it came to be such a famous and valuable part of our lives.
Meet … Viagra!
Viagra (sildenafil) is part of a classification of drugs known as Phosphodiesterase type 5 (PDE-5) inhibitors. PDE-5 inhibitors cause the smooth muscle cells in the walls of blood vessels to relax, allowing the rate of blood flow to increase as vascular resistance decreases. This is caused vasodilation, and drugs that cause this are called vasodilators. Vasodilators are frequently used to treat conditions such as hypertension, or high blood pressure, where decreasing the pressure of the blood within the blood vessels is necessary. In the case of Viagra, and similar PDE-5 medications, the vasodilation improves the ability of blood to flow into the penis, making it easier to get and keep an erection when sexually stimulated.
Now, the body contains about 11 different kinds of PDE, but only one type, PDE-5, is found in the penis. So Viagra’s function is actually quite simple: it blocks PDE-5, and does not affect the other PDE types, so it is able to target only the penis and allow the initializing enzyme cGMP to build up, increasing blood flow without affecting the rest of the body.
A Brief History of Viagra
Like many of our most revolutionary medications, the life history of Viagra began in a search for medicine to treat a cardiac condition. In the early 1990s, Pfizer pharmaceutical researchers were working on a compound called sildenafil. This drug was initially found to have promise as an effective treatment for hypertension and chest pains, or angina because it was capable of improving the circulation of blood throughout the body. When it came time to test the medication, it was discovered that while the medication was having some effect on hypertension that the subject rats were experiencing, it also was demonstrating an interesting side effect. The rats were showing marked changes in the frequency of their erections, leading researchers to venture that the drug may be useful as a treatment for impotence. Before they could market the medication as such, however, they had to test it out on people. They conducted a clinical trial of men and found that the drug did indeed help the body to achieve and maintain an erection.
Pfizer, realizing the potential that such a medication could have on the open market, decided to commercialize the drug as a remedy for men suffering from erectile dysfunction. They dubbed the drug “Viagra” and sought out approval from the Food and Drug Administration (FDA), getting that approval in March of 1998. Viagra became the first oral ED medication in the US and sold more than !1 billion in capsules from 1999 to 2000.
As the years went on, other ED pills joined Viagra on the market, though the “little blue pill” has maintained the greatest percentage of sales.
How Much Viagra Can You Take?
Viagra is available in three prescribed dosages: 25mg, 50mg, and 100mg. For some men with only mild ED, a low dosage of Viagra may be sufficient to improve their ability to have an erection, for more severe cases, the higher dosages will be needed. Other factors also make multiple dosages a necessity. It is important to work closely with your doctor to determine what the right dosage of the medication is for you. Your doctor will take into account a variety of factors from your medical history and lifestyle before he decides on a dosage to prescribe. Your age, how severe your erectile dysfunction is and if you have any previous experience taking Viagra will all be considered during this process. Your doctor will also look closely at your health status, especially any cardiac or circulatory issues, as well as any medications you’re are currently taking because Viagra could have a negative effect when combined with certain physical conditions or medications.

Side Effects: The Major and The Minor
Like any medication, Viagra does have its side effects. Generally, those side effects are very mild and very brief, such as facial flushing or a stuffy nose. Some side effects, however, can be a bit more lasting and, in some cases, more serious.
While it blocks the PDE-5, it has also been found to have some effect on PDE-6. PDE-6 is primarily located in the cone cells of your retina, resulting in Viagra occasionally affecting your color vision. You may notice a change in the way the colors green or blue look. Your vision may even have an overall bluish tinge for several hours after taking Viagra.
Another side effect concern involves a risk to people who take medications such as nitroglycerin. Nitroglycerin, often taken to treat angina, increases the amount of nitric oxide in the body, opening the arteries more fully so that oxygen-rich blood can get to the heart more efficiently. The problem is that Viagra also raises the amount of nitric oxide in the body, so taking the two medications could potentially cause your problems.
The vasodilation properties of Viagra have also been known to cause headaches, as the brain’s arteries may also dilate, causing an excess of pressure in the lining of the brain. Heart attacks are also a serious risk and the main reason that Viagra is a prescription medication rather than an over-the-counter.
Arguably the most well-known side effect of Viagra is a condition called priapism. Priapism plainly stated, is an erection that simply won’t go away. Unlike sexually-stimulated erections, priapism erections can occur without sexual stimuli. The worst part of priapism is that this type of erection can last longer than four hours, which is dangerous to the tissues of the penis. Though it is unusual, Viagra has been known to cause a reaction in some men, leading to the ischemic-type of priapism. Ischemic priapism means that the blood flows into the penis, but is unable to naturally flow back out. This loss of circulation deprives certain parts of the penis of oxygen, leading to a painful erection, tissue damage and scarring that can result in permanent impotence. Medical help must be sought out immediately to prevent lasting damage to the penis when priapism occurs.

Conclusion
History shows us that problems with erectile dysfunction have existed since ancient times. Today, however, we have accomplished what herbalists and physicians have attempted over and over again: we have found a way to successfully treat impotence. Viagra was the pioneer drug, the “little blue pill” that could free men from the stigma of impotence, boosting their confidence and improving, even saving, relationships. Even though many similar medications, including Cialis and Levitra, have made their way onto the market, Viagra has continued to be the go-to drug prescribed for men with erectile dysfunction. Once you’ve taken the time to learn more about Viagra, how it works, how much you can take and what it can really do for you, you will see why it is the top choice for so many.
eDrugstore facilitates access to a host of FDA-approved medications, including Viagra and other erectile dysfunction medications. To learn more about Viagra, erectile dysfunction and your sexual health, please visit the eDrugstore website.

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