Man seeking consult with a medical doctor.

ED Drugs Should Not Lose Effectiveness Over the Long Term

Don’t worry about developing a tolerance to your erectile dysfunction drug, such as that which occurs with opiates and certain other medications. However, if your underlying health problems worsen, you might need to take more of the ED drug to obtain the desired results. 

Unlike opiates and other addictive drugs, for which users develop a tolerance over time, erectile dysfunction drugs known as PDE5 inhibitors generally work for the long haul.

Some patients may find that they eventually need a bit more Viagra or Cialis to produce the same effect it did when they first started taking it. However, that is not usually indicative of a tolerance to the drug.

A Temporary Glitch?

You could just have a temporary problem linked to what you ate and drank around the time you took the drug. In cases like that, avoid such behavior in the future to lessen any possible interference with the onset and effectiveness of your ED drug.

In yet other cases, the need for more medication could point to a worsening of your underlying health problems that makes it even more difficult to get an erection than it was earlier. In such cases, it might be necessary to increase the dosage of the ED drug you’ve been taking. Alternatively, you might opt to switch to another of the PDE5 inhibitors to see if it produces the desired results for you.

Watch What You Eat and Drink

While most ED drugs can be taken with or without food, some of these medications will be slower to take effect if you take them after a heavy meal, particularly one that is high in fat content. It will take longer for your digestive system to break down the medication and move its active ingredient into your bloodstream if it’s simultaneously working to digest a heavy meal. In such cases, the effects of the drug might not be reduced at all but just simply delayed.

Having too much to drink before taking any of the ED drugs can also interfere with optimal erectile function. As most men have discovered much to their dismay, too much alcohol can make it almost impossible to get an erection at all. And for those who are able to get one, they may find that it doesn’t last until sexual activity is complete. And that can be even more embarrassing.

Underlying Medical Issues

Viagra and the other ED drugs known as PDE5 inhibitors are designed primarily to help men whose impotence is caused by insufficient blood flow to the penis. This kind of vascular compromise is closely associated with underlying health problems like atherosclerosis, the buildup of fatty plaques on artery walls; high blood pressure; diabetes; elevated cholesterol; and obesity.

If these conditions worsen, it can become increasingly difficult for your heart to deliver the sort of blood flow necessary to support erectile function. In these cases, work with your doctor to better combat the disease processes causing your impotence.

If you’re unable to reverse these underlying health problems, you may indeed need to take more of the ED drug you’ve been using to produce the type of results you desire.

Psychological Issues

And remember that it’s not just physiological problems that cause ED. Anxiety, depression, stress, and other psychological factors can also interfere with normal erectile function. If you suspect that you may be suffering from a psychological problem that’s exacerbating your ED, ask your doctor to refer you for appropriate counseling.

No matter which ED drug you prefer, you might find you can save both time and money by ordering it from, a longtime online facilitator based in Tempe, Arizona. In operation since the late 1990s, eDrugstore carries a full range of ED medications, including both brand-name and generic drugs.

What eDrugstore’s Prices Cover

Prices at eDrugstore cover not just the drug you’re ordering but a host of added-value services as well. Shipping is free, and by ordering online you’ll save yourself the headache of trips to and from the local pharmacy.

You say you don’t yet have a prescription? Not to worry, because eDrugstore has a convenient solution for you. Its complimentary online consultation service will match you up with a licensed U.S. physician who can authorize a prescription if appropriate. To learn more, visit eDrugstore’s Erectile Dysfunction page.

Don Amerman has spent more than three decades in the business of writing and editing. During the last 15 years, his focus has been on freelance writing. For almost all of his writing, He has done all of his own research, both online and off, including telephone and face-to-face interviews where possible. Don Amerman on Google+