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If the popular erectile dysfunction drugs don’t work for you, penile injection therapy offers another viable option for treating ED. It’s widely effective and hardly as frightening a prospect as it might seem.
Viagra and the other impotence drugs that followed in its wake have made it easier for millions of men to overcome their symptoms of intractable erectile dysfunction. Unfortunately, the little blue pill and its close relatives simply don’t work for everyone. For still others, taking oral ED medications is inadvisable because of underlying health conditions or potential interactions with other drugs they’re taking.
If you’re among the minority of ED patients for whom the oral drugs don’t deliver the desired results or are contraindicated for other medical reasons, there are a handful of other options available to you. One of the most consistently effective — and safe — options is penile injection therapy.
Not as Bad as It Sounds
If the very idea of sticking a needle into your penis is just a tad off-putting to you, you’re not alone. Although there are no statistics on this sensitive topic, it’s fair to suggest that preliminary discussion of the technique is cringe-inducing in most men who are first investigating this form of ED treatment.
However, according to the first-person accounts of several men who routinely use this form of therapy, the needle is tiny, the pinprick from the injection itself is barely noticeable, and the amount of medication injected is small. And on the upside, the erection-producing results of penile injection therapy are almost instantaneous.
Viagra, the first of the oral medications marketed for the treatment of ED, came on the market in the United States in 1998. Its active ingredient, sildenafil citrate, was first researched by Pfizer scientists as a possible treatment for angina and high blood pressure. While it failed to impress as a treatment for those ills, researchers soon realized that the medication was producing some unexpected results in male study participants. Most, including some who suffered from ED, were reporting that they found it easy to get an erection after taking the pill. Pfizer scrapped its earlier study and began looking into sildenafil citrate’s potential in the treatment of erectile dysfunction. The rest, of course, is history.
Another Serendipitous Discovery
A similarly serendipitous discovery led to the discovery of penile injection therapy more than two decades before FDA approval of Viagra. In 1977, a surgeon performing a bypass procedure accidentally injected papaverine — a muscle and blood vessel relaxant — into the groin area of an ED patient. Within minutes, the errant injection had produced a robust erection that lasted for roughly two hours.
Subsequent studies confirmed that papaverine injected directly into the penis increased blood flow within the penis, resulting in an erection. In 1983, British urologist Giles S. Brindley, M.D., conducted a study that showed papaverine injected into the penises of 11 impotent men enabled them to get robust erections and once again engage in intercourse.
Shocking Demonstration
At the 1983 conference of the Urodynamics Society in Las Vegas, Brindley secretly injected his penis with papaverine shortly before addressing conferees. Wearing loose-fitting workout pants, Brindley came to the podium to speak and shortly thereafter pulled down his pants to show his audience the wonders wrought by penile injection therapy. True story!
Although papaverine was the medication most often used in early penile injection therapy, it has since been joined by others, most notably phentolamine and alprostadil. The latter is a synthetic analog of a naturally occurring prostaglandin and has virtually the same effect as papaverine. Also marketed are compounds that combine two or more of the aforementioned medications.
Increases Blood Flow
Like the active ingredients in the PDE5 inhibitors (oral drugs), penile injection therapy’s medications facilitate increased blood flow to the penis. However, while the oral drugs affect multiple body systems to some extent, penile injection therapy’s effects are much more localized. For that reason, men who are taking nitrates or other antihypertensives generally can use penile injection therapy without risking a life-threatening drop in overall blood pressure. The same cannot be said of the PDE5 inhibitors, which should never be used concurrently with nitrate-based drugs.
Among the pros of penile injection therapy is its speed. An injection usually produces an erection within 10 to 20 minutes at the most. And it is price-competitive with the oral ED medications.
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Side Effects Mild
Side effects are generally mild but can include dizziness and headache. A more serious side effect can be an erection that lasts for an extended period of time and requires immediate medical attention. However, adjustments in the amount of medication injected can help to ensure such a problem does not recur.
The cost of penile injection therapy per injection ranges from less than $10 to nearly $40. Most expensive are the compounds marketed under the brand names Caverject and Edex. Both contain alprostadil as their active ingredient. A generic injectible virtually identical to Caverject and Edex costs as little as $10. Also available is a combination known as Trimix, which combines alprostadil, papaverine, and phentolamine.
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