man sleeping soundly thanks to Ramelteon

Why Ramelteon May Be the Best Prescription Sleep Medication


  • Ramelteon may be the best prescription sleep medications available.
  • This FDA-approved insomnia treatment is very effective and well tolerated. 
  • Ramelteon doesn’t cause addiction or produce withdrawal symptoms.
  • No medication is without side effects. Always consult your doctor before taking any sleep aid. 

Dr. Michael DiLeo
Latest posts by Dr. Michael DiLeo (see all)

Insomnia can literally turn your day into a nightmare. Not getting enough sleep can mean waking up groggy, having difficulty concentrating, gaining weight, and getting sick more often. 

There are many prescription medications on the market to help you fall asleep. Most come with a high risk of side effects or other limitations of use. Ramelteon, the FDA-approved generic version of Rozerem, might be the best prescription sleep medication available. 

This new type of treatment mimics the natural sleep cycles of your body and has a high safety profile. 

Here are the main advantages of ramelteon over other prescription sleep medications.

Ramelteon Has a Targeted Mechanism of Action

Ramelteon is known as melatonin agonist. It binds itself to melatonin receptors, initiating a complex mechanism to promote sleep. This is different from melatonin itself. By filling the melatonin receptors, the body is stimulated to make its own melatonin — that is, the ideal melatonin.

What makes this drug so special is its precise targeting. It hits the exact spots that are responsible for our sleep-wake cycles. As a result, it can help you sleep better without unnecessary interference with other neurotransmitter systems.

Ramelteon Is Approved by the FDA

Unlike melatonin, a popular sleep supplement, ramelteon is an FDA-approved drug for the treatment of insomnia. While synthetic melatonin is easily available over the counter, there is a lot of confusion for consumers looking to use it as a sleep aid. 

First, melatonin supplements are sold in different dosages — and it’s sometimes difficult to find the minimal effective dose. Also, many supplements combine different natural ingredients. Since supplements are not as strictly regulated as medicines, there’s a greater risk of taking something that won’t work for you or may make you feel worse.

Ramelteon Is Well Tolerated

What good is an effective treatment if it causes strong side effects? You basically get rid of one problem only to experience issues somewhere else. Ramelteon, like any other medication, may cause adverse effects, but it’s generally well tolerated by patients. 

No Morning Drowsiness

When you compare ramelteon with other prescription sleep medications, like Ambien (zolpidem), the risk of feeling unwell the next day is lower. For people who need to be alert in the morning to perform work duties or other obligations, this is a game changer. 

Fewer Cognitive Effects

You want to get a good night’s sleep, but you don’t want to sacrifice mental performance in the process. Other sleep aids put you at risk of cognitive impairment, but with ramelteon, brain fog is less of an issue. You get your nightly zzz’s without feeling confused or struggling to stay awake

Ramelteon Isn’t Addictive

A common concern with prescription sleep medication, like benzodiazepines, is the possibility of becoming dependent on them. 

While a general rule for sleep drugs is to use them only as needed, preferably not longer than one or two weeks, ramelteon is a safer option for longer-term use as it doesn’t cause addiction.

Ramelton Has a Low Risk of Abuse

Like ramelteon, sleep medications like Ambien and Xanax are available only by prescription. Unlike these other medications, however, ramelteon is not classified as a controlled substance. This suggests higher safety of the drug as it doesn’t have the potential for abuse. 

Ramelteon Has No Withdrawal Symptoms

Having difficulty sleeping for one or two nights is not a big problem. Chronic insomnia, however, is a different story. People with long-lasting sleep disturbances need effective solutions they can take over a longer time. 

Many prescription medications cause withdrawal symptoms, so getting off them requires a tapering schedule. According to a study on people with insomnia, ramelteon didn’t cause withdrawal symptoms even when taken daily for six months. 

Fewer Dangerous Interactions

Interactions with drugs and other substances are a big concern with prescription sleep medications. Rameltenon may interact with certain treatments but it has an overall better safety profile compared to other sleep aids. 

Here are the known drug interactions for ramelteon::

  • Fluvoxamine (used in the treatment of obsessive compulsive disorder)
  • Rifampin (used for tuberculosis and other bacterial infections)
  • Ketoconazole and fluconazole (antifungal medications)
  • Donepezil (dementia treatment)
  • Doxepin (antidepressant)

Less Interaction With Alcohol

A general precaution is never to mix sleeping pills with alcohol. The same applies to ramelteon, but the drug is considered to have fewer adverse interactions with alcohol than other prescription sleep medications. Still, the FDA label advises to avoid the combination as it may have an addictive effect.

Ramelteon Is Safer for Higher-Risk Patients

Your doctor will ultimately decide if the treatment is safe for you. However, in contrast with other sleep medicines, ramelteon is quite safe for higher-risk groups, such as the elderly and those with chronic respiratory conditions. 

Suitable for the Elderly

Seniors often have a limited choice of sleep medication due to underlying health conditions. Since ramelteon is a relatively safe treatment, it’s a preferred choice for older adults. 

According to a study of people over 65 with chronic insomnia, ramelteon didn’t have a negative impact on balance, memory, or mobility. 

elderly man sleeping profoundly

Minimal Respiratory Depression

Ramelteon is well tolerated by people with chronic obstructive pulmonary disease (COPD) and doesn’t cause respiratory depressant effects. 

The drug is different in this respect from other sleep medications, such as benzodiazepines, making it safer for patients with some respiratory conditions. 

To learn more about ramelteon, check out our Ramelteon FAQ.

Get Best Sleep Medication at

If you’re looking for an effective and safe insomnia treatment, ramelteon may be the best prescription sleep medication on the market right now. Always consult with your doctor before taking it. 

eDrugstore’ offers a convenient telemedicine consultation option. Our U.S.-licensed physicians will help you decide if ramelteon is the right choice for you and write your prescription. When you shop with eDrugstore, your consultation and shipping are always free.

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