Nexium helps relieve heartburn and other symptoms of acid reflux by reducing the amount of stomach acid your body produces. It does this by acting as a “proton pump inhibitor” - in other words, it turns off some of the pumps in your stomach that make acid. This, in turn, prevents that acid from damaging your esophagus or from causing pain and indigestion.
Unlike over the counter antacids, Nexium is taken every day, long before heartburn and other GERD symptoms appear. This means you never experience the pain and pressure associated with acid reflux. Since Nexium reduces the amount of acid in the stomach, it helps prevent future damage to the esophagus.
In fact, Nexium even helps heal erosions and other damage caused by acid reflux. Erosions often heal between 4 – 8 weeks after beginning treatment. Nexium is also used to maintain healing and prevent resurgence of erosive esophagitis over longer periods of time.
Nexium also helps people over 60 who have already had an ulcer reduce the risk of another stomach ulcer, especially ulcers associated with pain medications (asprin, ibuprofen, etc.).
In combination with amoxicillin and clarithromycin, Nexium helsp treat patients with duodenal ulcer disease and H. pylori infections.
20mg doses are recommended to help clear up symptoms of GERD, taken once a day for 4 weeks. By reducing the amount of acid in the stomach, it can help alleviate heartburn, as less acid is able to make its way up the esophagus and cause pain and discomfort. Nexium performs well in clinical trials when compared to placebos.
Nexium helps heal erosive esophagitis over a 4-8 week period and also maintain healing over longer periods. It is common for most erosions to heal during that first 4-8 week period. Patients taking Nexium stay in remission from erosive esophagitis significantly longer than those taking placebos. Nexium also helps reduce heartburn and other acid reflux symptoms in patients with erosive esophagitis.
While there are several generic proton pump inhibitors, there are no generic equivalents of Nexium available in the United States. A generic version is available in Canada from Apotex, however, its price is comparable to that of Nexium. Always consult your doctor before trying a different proton pump inhibitor, even if it seems similar to Nexium.
Possible Nexium side effects are headache, diarrhea, flatulence, abdominal pain, constipation, dry mouth, nausea, and others. Adverse reactions to Nexium are uncommon. However, bone fractures are also possible while taking Nexium. Talk to your doctor about the possibility of taking a calcium supplement. As with any medication, if you experience an allergic reaction, contact emergency medical professionals immediately.
While Nexium overdoses are unusual, possible reactions include confusion, drowsiness, nausea, headache, tachycardia, dry mouth, and other reactions similar to possible Nexium side effects. As there is no antidote and Nexium cannot be removed by dialysis, overdose treatment is limited to treatment of the symptoms.
Make sure to tell your doctor if youve ever had any kind of liver disease. This could effect your dosage of Nexium, require monitoring, or even prevent you from being able to take Nexium. Always tell your doctor if you are pregnant or plan to become pregnant before starting to take Nexium. You are not advised to take Nexium while breastfeeding – talk to your doctor. Make sure your doctor has your complete medical history before starting any new prescription medication. Nexium does not require a specific diet or activity schedule unless your doctor recommends it.
Always make sure to let your doctor know about any medication you are taking before starting Nexium. This is particularly important if you are currently taking diazepam (Valium), nelfinavir (Viracept), digoxin (Lanoxin), ketoconaxole (Nixoral), any medication containing iron, or medications containing St. Johns Wort (Hypericum perforatum). It is also important to let your doctor know if youre currently taking clopidogrel, as Nexium can reduce the clopidogrels effectiveness. Antacids do not produce unwanted interactions when combined with Nexium.
Important Patient InformationESOMEPRAZOLE DELAYED-RELEASE CAPSULE - ORAL (ES-oh-MEP-ra-zole) COMMON BRAND NAME(S): Nexium
IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.
USES: Esomeprazole is used to treat certain stomach and esophagus problems (such as acid reflux, ulcers). It works by decreasing the amount of acid your stomach makes. It relieves symptoms such as heartburn, difficulty swallowing, and persistent cough. This medication helps heal acid damage to the stomach and esophagus, helps prevent ulcers, and may help prevent cancer of the esophagus. Esomeprazole belongs to a class of drugs known as proton pump inhibitors (PPIs). If you are self-treating with this medication, over-the-counter esomeprazole products are used to treat frequent heartburn (occurring 2 or more days a week). Since it may take 1 to 4 days to have full effect, these products do not relieve heartburn right away. For over-the-counter products, carefully read the package instructions to make sure the product is right for you. Check the ingredients on the label even if you have used the product before. The manufacturer may have changed the ingredients. Also, products with similar brand names may contain different ingredients meant for different purposes. Taking the wrong product could harm you.
HOW TO USE: Read the Medication Guide and the Patient Information Leaflet if available from your pharmacist before you start taking esomeprazole and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Take this medication by mouth as directed by your doctor, usually once daily, at least 1 hour before a meal. If you are self-treating, follow all directions on the product package. The dosage and length of treatment are based on your medical condition and response to treatment. Do not increase your dose or take this drug more often than directed. If you have any questions, ask your doctor or pharmacist. Do not crush or chew this medication. Swallow the capsules whole. If you have difficulty swallowing this medication whole, you may open the capsule and sprinkle the contents into a tablespoon of unheated applesauce. Swallow the applesauce mixture right away without chewing it. Do not prepare the mixture ahead of time for later use. Doing so may destroy the drug. If needed, antacids may be taken along with this medication. If you are also taking sucralfate, take esomeprazole at least 30 minutes before sucralfate. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. Continue to take this medication for the prescribed length of treatment even if you are feeling better. If you are self-treating with the over-the-counter product, do not take it for more than 14 days unless directed by your doctor. Tell your doctor if your condition persists or worsens. If you are self-treating, tell your doctor if your heartburn persists after 14 days or if you need to use this medication more than once every 4 months. The risk of side effects goes up over time. Ask your doctor how long you should take this medication. If you think you may have a serious medical problem, get medical help right away.
SIDE EFFECTS: See also Precautions section. Headache or abdominal pain may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: symptoms of a low magnesium blood level (such as unusually fast/slow/irregular heartbeat, persistent muscle spasms, seizures), signs of lupus (such as rash on nose and cheeks, new or worsening joint pain). This medication may rarely cause a severe intestinal condition (Clostridium difficile-associated diarrhea) due to a type of bacteria. Do not use anti-diarrhea or opioid medications if you have any of the following symptoms because these products may make them worse. Tell your doctor right away if you develop: persistent diarrhea, abdominal or stomach pain/cramping, fever, blood/mucus in your stool. Rarely, proton pump inhibitors (such as esomeprazole) have caused vitamin B-12 deficiency. The risk is increased if they are taken every day for a long time (3 years or longer). Tell your doctor right away if you develop symptoms of vitamin B-12 deficiency (such as unusual weakness, sore tongue, or numbness/tingling of the hands/feet). A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing, signs of kidney problems (such as change in the amount of urine). This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
PRECAUTIONS: Before taking esomeprazole, tell your doctor or pharmacist if you are allergic to it; or to similar drugs (such as lansoprazole, omeprazole); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, lupus. Some symptoms may actually be signs of a more serious condition. Get medical help right away if you have: heartburn with lightheadedness/sweating/dizziness, chest/jaw/arm/shoulder pain (especially with shortness of breath, unusual sweating), unexplained weight loss. In addition, before you self-treat with this medication, get medical help right away if you have any of these signs of a serious condition: trouble/pain swallowing food, bloody vomit, vomit that looks like coffee grounds, bloody/black stools, heartburn for over 3 months, frequent chest pain, frequent wheezing (especially with heartburn), nausea/vomiting, stomach pain. Proton pump inhibitors (such as esomeprazole) may increase your risk for bone fractures, especially with longer use, higher doses, and in older adults. Talk with your doctor or pharmacist about ways to prevent bone loss/fracture, such as by taking calcium (such as calcium citrate) and vitamin D supplements. Children may be more sensitive to the side effects of this drug, especially fever, cough, and infections of the nose/throat/airways. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. It is unknown if this medication passes into breast milk. However, similar drugs pass into breast milk. The effects on a nursing infant are unknown. Consult your doctor before breast-feeding.
DRUG INTERACTIONS: See also How to Use section. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Some products that may interact with this drug include: cilostazol, clopidogrel, methotrexate (especially high-dose treatment), rifampin, St John's wort. Some products need stomach acid so that the body can absorb them properly. Esomeprazole decreases stomach acid, so it may change how well these products work. Some affected products include atazanavir, erlotinib, nelfinavir, pazopanib, rilpivirine, certain azole antifungals (itraconazole, ketoconazole, posaconazole), among others. Esomeprazole is very similar to omeprazole. Do not use any medications containing omeprazole while using esomeprazole. This medication may interfere with certain laboratory tests, possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.
OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: confusion, extreme sweating, blurred vision, or unusually fast heartbeat.
MISSED DOSE: If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.
STORAGE: Store at room temperature away from moisture. Do not store in the bathroom. Keep all medications away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
This product information is intended for United States residents only. Before prescribing, please refer to the patient information. You can view the document and also download it on your computer. You may also consider printing out a copy for yourself. View US Prescribing Information - PDF Version
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