{"id":33450,"date":"2022-09-27T14:50:39","date_gmt":"2022-09-27T07:50:39","guid":{"rendered":"https:\/\/www.edrugstore.com\/blog\/?p=33450"},"modified":"2025-02-13T10:43:42","modified_gmt":"2025-02-13T03:43:42","slug":"over-the-counter-nitric-oxide-for-ed","status":"publish","type":"post","link":"https:\/\/www.edrugstore.com\/blog\/erectile-dysfunction\/over-the-counter-nitric-oxide-for-ed\/","title":{"rendered":"Over-the-Counter Nitric Oxide for ED: Does It Work?"},"content":{"rendered":"<p><b>Highlights\u00a0\u00a0<\/b><\/p>\n<ul>\n<li aria-level=\"1\"><b>Over-the-counter nitric oxide supplements may help with ED and offer other benefits.<\/b><\/li>\n<li aria-level=\"1\"><b>Viagra and its active component sildenafil help the body produce more nitric oxide to improve blood flow to the penis.<\/b><\/li>\n<li aria-level=\"1\"><b>Doctors have found that OTC nitric oxide supplements improve the effects of tadalafil.<\/b><\/li>\n<li aria-level=\"1\"><b>Nitric oxide supplement ingredients like L-arginine and L-citrulline produce few side effects.\u00a0<\/b><\/li>\n<\/ul>\n<hr \/>\n<p><span style=\"font-weight: 400;\">Nitric oxide is the magic behind Viagra. Sildenafil, the active ingredient in Viagra, works by <\/span><a href=\"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/abs\/10.1067\/mcp.2001.117995\"><span style=\"font-weight: 400;\">enhancing<\/span><\/a><span style=\"font-weight: 400;\"> the action of nitric oxide on blood vessels, increasing blood flow to the penis (and throughout the body). Because Viagra works through the nitric oxide pathway, over-the-counter nitric oxide supplements may achieve similar effects. Can these OTC nitric oxide supplements improve your erections?\u00a0<\/span><\/p>\n<h3>What Are Over-the-counter Nitric Oxide Supplements?<\/h3>\n<p><span style=\"font-weight: 400;\">You may find over-the-counter nitric oxide supplements online and get the impression that these products contain nitric oxide that your body can readily put to use. However, over-the-counter nitric oxide products do not contain nitric oxide. They contain ingredients that help your body produce more nitric oxide. It is impractical \u2014 and may be impossible \u2014 to include nitric oxide in a supplement.<\/span><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<h4>What Is Nitric Oxide?<\/h4>\n<p><span style=\"font-weight: 400;\">Nitric oxide (NO) is a colorless gas with a sharp odor. It is also known as nitrogen oxide or nitrogen monoxide. Do not confuse it with nitrogen dioxide (NO2) or nitrous oxide (N2O). The former is a pollutant, and the latter an anesthetic, often called laughing gas.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">From a biological perspective, nitric oxide is a messenger molecule that plays a role in many biological processes. Its lifetime is only a <\/span><a href=\"https:\/\/www.pnas.org\/doi\/10.1073\/pnas.98.1.355\"><span style=\"font-weight: 400;\">few seconds or less<\/span><\/a><span style=\"font-weight: 400;\">. It crosses membranes easily, however, performing its messaging and signaling duties almost instantly.<\/span><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<p><a href=\"https:\/\/www.edrugstore.com\/bg-ed\/\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-40406 size-full\" src=\"https:\/\/www.edrugstore.com\/blog\/wp-content\/uploads\/2024\/01\/27122024-Generic-Viagra.png\" alt=\"Generic Viagra for erectile dysfunction\" width=\"745\" height=\"300\" srcset=\"https:\/\/www.edrugstore.com\/blog\/wp-content\/uploads\/2024\/01\/27122024-Generic-Viagra.png 745w, https:\/\/www.edrugstore.com\/blog\/wp-content\/uploads\/2024\/01\/27122024-Generic-Viagra-300x121.png 300w\" sizes=\"auto, (max-width: 745px) 100vw, 745px\" \/><\/a><\/p>\n<h4>Where Nitric Oxide Originates<\/h4>\n<p><span style=\"font-weight: 400;\">The body synthesizes nitric oxide from substances like <\/span><a href=\"https:\/\/www.edrugstore.com\/blog\/current-health-news\/should-men-with-ed-take-l-arginine-supplements\/\"><span style=\"font-weight: 400;\">L-arginine<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21195829\/\"><span style=\"font-weight: 400;\">L-citrulline<\/span><\/a><span style=\"font-weight: 400;\">. It uses specialized enzymes to derive nitric oxide from these compounds. Over-the-counter nitric oxide supplements contain ingredients like L-arginine and L-citrulline. By making these available to the body in significant amounts, they may cause more nitric oxide to form.<\/span><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<h4>How Viagra Uses Nitric Oxide to Help Erections<\/h4>\n<p><span style=\"font-weight: 400;\">Viagra does not contain nitric oxide. Its active compound is <\/span><a href=\"https:\/\/www.edrugstore.com\/erectile-dysfunction\/sildenafil-citrate\/\"><span style=\"font-weight: 400;\">sildenafil<\/span><\/a><span style=\"font-weight: 400;\">, a phosphodiesterase 5 inhibitor. By inhibiting this substance, sildenafil stimulates the body to produce more nitric oxide.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The inner lining of the blood vessels uses nitric oxide to send a message to the surrounding smooth muscles to relax. When the muscles relax, the blood vessels dilate, allowing more blood to pass through. This effect can reduce blood pressure and enhance your erections.\u00a0<\/span><\/p>\n<h3>The Health Benefits of Nitric Oxide Supplements<\/h3>\n<p><span style=\"font-weight: 400;\">Nitric oxide is an essential biological messenger molecule. Physical exercise <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4382985\/\"><span style=\"font-weight: 400;\">enhances its production<\/span><\/a><span style=\"font-weight: 400;\"> in the muscles. By providing more raw materials for nitric oxide production, over-the-counter nitric oxide supplements may help the body make more NO.<\/span><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<h4>Nitric Oxide Supplements May Play a Role in Muscular \u201cPumps\u201d<\/h4>\n<p><span style=\"font-weight: 400;\">Physical exercise increases NO production in muscles. And NO relaxes smooth muscles, allowing blood vessels to dilate and let more blood through. Therefore, NO may play a role in the muscular \u201cpumps\u201d you get when working out.\u00a0<\/span><\/p>\n<h4>Nitric oxide may help your \u201cpumps.\u201d<\/h4>\n<figure id=\"attachment_33452\" aria-describedby=\"caption-attachment-33452\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/www.edrugstore.com\/blog\/wp-content\/uploads\/2022\/09\/2.jpeg-65_11zon.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-33452\" title=\"Fit man working out\" src=\"https:\/\/www.edrugstore.com\/blog\/wp-content\/uploads\/2022\/09\/2.jpeg-65_11zon.jpg\" alt=\"Fit man working out\" width=\"600\" height=\"400\" srcset=\"https:\/\/www.edrugstore.com\/blog\/wp-content\/uploads\/2022\/09\/2.jpeg-65_11zon.jpg 600w, https:\/\/www.edrugstore.com\/blog\/wp-content\/uploads\/2022\/09\/2.jpeg-65_11zon-300x200.jpg 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><\/a><figcaption id=\"caption-attachment-33452\" class=\"wp-caption-text\"><em>Nitric oxide may help your \u201cpumps.\u201d<\/em><\/figcaption><\/figure>\n<p><span style=\"font-weight: 400;\">Some people take over-the-counter nitric oxide supplements to help them work out more and recover faster following workouts.<\/span><\/p>\n<p><a href=\"https:\/\/journals.lww.com\/nsca-jscr\/Fulltext\/2010\/05000\/Citrulline_Malate_Enhances_Athletic_Anaerobic.9.aspx\"><span style=\"font-weight: 400;\">Researchers have found<\/span><\/a><span style=\"font-weight: 400;\"> that citrulline malate, an ingredient in some nitric oxide supplements, enhances anaerobic muscle performance and shortens recovery times. The compound may significantly reduce muscle soreness.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Increased blood flow to the muscles may hasten the delivery of essential nutrients and the evacuation of by-products that cause muscle soreness.\u00a0<\/span><\/p>\n<h4>OTC Nitric Oxide May Help Achieve and Maintain Erections<\/h4>\n<p><span style=\"font-weight: 400;\">By improving blood flow to the penis, nitric oxide supplements may help trigger erections and maintain them longer, enhancing sexual performance.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Although scientific evidence is scant in this respect, <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7261690\/\"><span style=\"font-weight: 400;\">some research<\/span><\/a><span style=\"font-weight: 400;\"> suggests that quality over-the-counter nitric oxide supplements may help drugs like <\/span><a href=\"https:\/\/www.edrugstore.com\/erectile-dysfunction\/buy-viagra\/\"><span style=\"font-weight: 400;\">Viagra<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.edrugstore.com\/erectile-dysfunction\/cialis\/\"><span style=\"font-weight: 400;\">Cialis<\/span><\/a><span style=\"font-weight: 400;\"> achieve better results. L-arginine is the compound that may be responsible for these effects.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">L-citrulline may also help boost erections and sexual performance, but it\u2019s <\/span><a href=\"https:\/\/www.goldjournal.net\/article\/S0090-4295(10)01661-4\/fulltext\"><span style=\"font-weight: 400;\">not as effective<\/span><\/a><span style=\"font-weight: 400;\"> as sildenafil or <\/span><a href=\"https:\/\/www.edrugstore.com\/erectile-dysfunction\/tadalafil-tabs\/\"><span style=\"font-weight: 400;\">tadalafil<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<h4>Nitric Oxide Supplements May Help with High Blood Pressure<\/h4>\n<p><span style=\"font-weight: 400;\">High blood pressure, one of the conditions that make up metabolic syndrome, occurs when the circulating blood exerts high pressure on the walls of blood vessels. By allowing the blood vessels to dilate, NO creates more space for blood to flow through. Thus, it reduces the pressure that blood flow exerts on the blood vessel walls.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Researchers <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8109558\/\"><span style=\"font-weight: 400;\">have noted<\/span><\/a><span style=\"font-weight: 400;\"> that people with high blood pressure may be unable to generate enough nitric oxide. This impaired nitric oxide production reduces the flexibility of blood vessels and arteries, causing high blood pressure.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">OTC nitric oxide may help such people regain blood vessel flexibility and improve their blood pressure.<\/span><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<h4>Nitric Oxide Supplements May Help Manage Type 2 Diabetes<\/h4>\n<p><span style=\"font-weight: 400;\">The links between nitric oxide and type 2 diabetes aren\u2019t clear. Researchers <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2927936\/\"><span style=\"font-weight: 400;\">have found<\/span><\/a><span style=\"font-weight: 400;\">, however, that diabetes patients don\u2019t produce as much nitric oxide as healthy people. They don\u2019t know whether impaired NO production contributes to diabetes or is a result of diabetes.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">We know that diabetes damages blood vessels, causing high blood pressure over time. And NO production may be a factor in that equation.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Researchers already suspect that nitric oxide supplements can improve NO production in diabetes patients. They also know that L-arginine supplementation <\/span><a href=\"https:\/\/diabetesjournals.org\/care\/article\/24\/5\/875\/23635\/Long-Term-Oral-l-Arginine-Administration-Improves\"><span style=\"font-weight: 400;\">can fight diabetes<\/span><\/a><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">L-arginine may even <\/span><a href=\"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/10.1111\/j.1463-1326.2012.01615.x\"><span style=\"font-weight: 400;\">delay the progression<\/span><\/a><span style=\"font-weight: 400;\"> of the disease. However, we need more research to prove the suspected links between NO and diabetes.<\/span><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<h4>Other Benefits of Nitric Oxide Supplementation<\/h4>\n<p><span style=\"font-weight: 400;\">People attribute many other anecdotal benefits to NO supplements, like:\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Enhancing the healing of diabetic lesions<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Helping with weight loss<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fighting the common cold<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Improving trauma recovery<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Reducing the symptoms of altitude sickness<\/span><\/li>\n<\/ul>\n<h3>The Risks and Side Effects of Over-the-counter Nitric Oxide Supplements<\/h3>\n<p><span style=\"font-weight: 400;\">People generally tolerate over-the-counter nitric oxide supplements well. Whether you take nitric oxide for ED or other conditions, you should know that it can have some side effects.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Compounds like L-arginine may cause an upset stomach, nausea, headaches, palpitations, and heartburn. Some of the side effects of these supplements may be more severe.\u00a0<\/span><\/p>\n<h4><a href=\"https:\/\/www.edrugstore.com\/blog\/wp-content\/uploads\/2022\/09\/3.jpeg-63_11zon.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-33453\" title=\"Man in pain sitting on the bed\" src=\"https:\/\/www.edrugstore.com\/blog\/wp-content\/uploads\/2022\/09\/3.jpeg-63_11zon.jpg\" alt=\"Man in pain sitting on the bed\" width=\"600\" height=\"400\" srcset=\"https:\/\/www.edrugstore.com\/blog\/wp-content\/uploads\/2022\/09\/3.jpeg-63_11zon.jpg 600w, https:\/\/www.edrugstore.com\/blog\/wp-content\/uploads\/2022\/09\/3.jpeg-63_11zon-300x200.jpg 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><\/a><\/h4>\n<h4>Low Blood Pressure<\/h4>\n<p><span style=\"font-weight: 400;\">By relaxing the blood vessels and dilating them, nitric oxide lowers blood pressure. Those with high blood pressure may welcome this effect. But those whose blood pressure is already low won\u2019t appreciate having it lowered further.<\/span><i><span style=\"font-weight: 400;\">\u00a0<\/span><\/i><\/p>\n<h4>Liver Cirrhosis<\/h4>\n<p><span style=\"font-weight: 400;\">Nitric oxide supplements containing compounds like L-arginine and L-citrulline may hurt liver function. Those who already suffer from cirrhosis or other liver problems should avoid these supplements.<\/span><i><span style=\"font-weight: 400;\">\u00a0<\/span><\/i><\/p>\n<h4>Higher Chance of Death After a Heart Attack<\/h4>\n<p><span style=\"font-weight: 400;\">While in general, NO supplements have cardiovascular benefits, taking them after a heart attack may make matters worse, according to the <\/span><a href=\"https:\/\/www.mayoclinic.org\/drugs-supplements-l-arginine\/art-20364681\"><span style=\"font-weight: 400;\">Mayo Clinic<\/span><\/a><span style=\"font-weight: 400;\">. Patients who take L-arginine post heart attack may be at higher risk for repeat heart attacks and death.\u00a0<\/span><\/p>\n<h3>eDrugstore Can Help<\/h3>\n<p><span style=\"font-weight: 400;\">The available evidence indicates that boosting nitric oxide for ED may make sense. NO supplements that include L-arginine may boost the effects of FDA-approved ED solutions like Viagra and Cialis. In addition to these lifestyle medications, we also carry <\/span><a href=\"https:\/\/www.edrugstore.com\/nitric-oxide\/\"><span style=\"font-weight: 400;\">over-the-counter nitric oxide<\/span><\/a><span style=\"font-weight: 400;\">. Unlike FDA-approved drugs, nitric oxide supplements do not require a prescription.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">When you order with eDrugstore, telehealth visits and shipping are always free.<\/span><\/p>\n<p>&nbsp;<\/p>\n<h2>Frequently Asked Questions<\/h2>\n<h3>What are nitric oxide supplements?<\/h3>\n<p><span data-contrast=\"auto\">Nitric oxide supplements are dietary products designed to increase levels of nitric oxide in the body. Nitric oxide is a molecule that helps relax and widen blood vessels, promoting better blood flow, which is essential for achieving and <\/span><span data-contrast=\"auto\">maintaining erections. These supplements typically contain ingredients like L-arginine, citrulline, or beetroot, which support nitric oxide production.<\/span><\/p>\n<h3>What are the best supplements for erections?<\/h3>\n<p><span data-contrast=\"auto\">The <\/span><span data-contrast=\"auto\">best supplements for erections typically include L-arginine, citrulline, beetroot extract, and ginseng. These ingredients help enhance nitric oxide production, improve blood <\/span><span data-contrast=\"auto\">flow, and support overall erectile function. Other popular options include zinc, magnesium, and DHEA, which have been linked to improved testosterone levels and sexual health.<\/span><\/p>\n<h3>Does nitric oxide supplement help with erectile dysfunction cure?<\/h3>\n<p><span data-contrast=\"auto\">While <\/span><span data-contrast=\"auto\">nitric oxide supplements can improve blood flow, they are not a guaranteed cure for erectile dysfunction (ED). ED can be caused by various factors like hormonal imbalances, psychological issues, or underlying health conditions. Supplements may help alleviate some symptoms, particularly if mild or related to poor circulation, but addressing the root cause is essential for effective ED treatment.<\/span><\/p>\n<h3>Can nitric oxide supplements improve erectile dysfunction treatment?<\/h3>\n<p><span data-contrast=\"auto\">Yes, <\/span><span data-contrast=\"auto\">nitric oxide supplements can aid in improving erectile dysfunction treatment by promoting better blood flow. However, they are often more effective when combined with a comprehensive approach, such as lifestyle changes, counseling, or medications like PDE5 inhibitors (e.g., Viagra, Cialis). Supplements may not work as effectively alone in all cases, especially if ED is caused by underlying medical conditions.<\/span><\/p>\n<h3>Can nitric oxide supplements improve erectile dysfunction caused by porn-induced erectile dysfunction (PIED)?<\/h3>\n<p><span data-contrast=\"auto\">Yes, <\/span><span data-contrast=\"auto\">nitric oxide supplements may help with porn-induced erectile dysfunction (PIED) by promoting better blood flow and improving overall vascular function. However, addressing the r<\/span><span data-contrast=\"auto\">oot cause, such as reducing dependency on pornography and managing psychological triggers, is also crucial for effective treatment. Supplements can support physical aspects of ED, but behavioral or psychological interventions are often necessary.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><script type=\"application\/ld+json\">\n{\n  \"@context\": \"https:\/\/schema.org\",\n  \"@type\": \"FAQPage\",\n  \"mainEntity\": [{\n    \"@type\": \"Question\",\n    \"name\": \"What are nitric oxide supplements?\",\n    \"acceptedAnswer\": {\n      \"@type\": \"Answer\",\n      \"text\": \"Nitric oxide supplements are dietary products designed to increase levels of nitric oxide in the body. Nitric oxide is a molecule that helps relax and widen blood vessels, promoting better blood flow, which is essential for achieving and maintaining erections. 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Viagra and its active component sildenafil help the body produce more nitric oxide to improve blood flow to the penis. Doctors have found that OTC nitric oxide supplements improve the effects of tadalafil. Nitric oxide supplement ingredients like L-arginine and L-citrulline produce [&hellip;]<\/p>\n","protected":false},"author":22,"featured_media":33454,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_autoblog_aioseo_focus_keyphrase":"","_autoblog_aioseo_title":"","_autoblog_aioseo_description":"","footnotes":""},"categories":[20],"tags":[],"class_list":["post-33450","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-erectile-dysfunction"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO Pro 4.9.10 - aioseo.com -->\n\t<meta name=\"description\" content=\"Are you looking for an erectile dysfunction cure? 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