{"id":32949,"date":"2022-06-30T11:06:24","date_gmt":"2022-06-30T04:06:24","guid":{"rendered":"https:\/\/www.edrugstore.com\/blog\/?p=32949"},"modified":"2026-03-31T03:06:32","modified_gmt":"2026-03-30T20:06:32","slug":"can-low-testosterone-cause-depression","status":"publish","type":"post","link":"https:\/\/www.edrugstore.com\/blog\/testosterone\/can-low-testosterone-cause-depression\/","title":{"rendered":"Can Low Testosterone Cause Depression?"},"content":{"rendered":"<p><b>Highlights<\/b><\/p>\n<ul>\n<li aria-level=\"1\"><b>Testosterone plays an important role in your physical and mental health.<\/b><\/li>\n<li aria-level=\"1\"><b>Low testosterone (low T) is linked to mood changes like depression.\u00a0<\/b><\/li>\n<li aria-level=\"1\"><b>Testosterone replacement therapy (TRT) has shown promise in treating depression in men with low T.\u00a0<\/b><\/li>\n<li aria-level=\"1\"><b>TRT may not work for everyone, so it\u2019s best to speak with a provider about your treatment options.\u00a0<\/b><\/li>\n<li aria-level=\"1\"><b>You can test for low T in the comfort of your own home with at-home test kits available online.<\/b><\/li>\n<\/ul>\n<hr \/>\n<p><span style=\"font-weight: 400;\">Testosterone is responsible for more than your sex drive. Low testosterone (low T) is linked to depression, anxiety, and irritability. If you suspect you have low T, you can now test at home to determine if you need treatment.<\/span><\/p>\n<h3>What Is Testosterone?<\/h3>\n<p><span style=\"font-weight: 400;\">Testosterone is a male sex hormone produced by both men and women. Men produce testosterone in higher concentrations than women. While testosterone is commonly linked to aggressive behavior, it\u2019s actually a critical hormone for health and human development.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Testosterone plays an important role in many bodily functions, such as:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Body fat distribution<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bone growth and density<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Deepening of voice during puberty<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Muscle size and strength<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sperm production<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sex drive (libido)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Testes and penis development<\/span><\/li>\n<\/ul>\n<h4>Symptoms of Low Testosterone<\/h4>\n<p><span style=\"font-weight: 400;\">Low testosterone (low T) is also known as hypogonadism. This condition can affect both your physical and emotional health. Low T can affect men across the lifespan, but it is more common in older men.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">One of the first indicators of low T is a change to your sex drive. In men, this may make it more difficult to get an erection, to keep an erection, or to conceive with a partner. However, having a reduced sex drive doesn\u2019t necessarily mean you have low T.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Common symptoms of low testosterone include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Erectile dysfunction<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fatigue<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mood changes, irritability, anxiety, or depression<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Poor memory or difficulty concentrating<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Reduced lean muscle mass or muscle weakness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Reduced sex drive<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">These symptoms overlap with other mental and physical health conditions. A combination of these symptoms is more likely to be related to your testosterone levels. It\u2019s important to speak to a provider if you experience symptoms of low T so you can determine the right diagnosis.<\/span><\/p>\n<h3>Does Low Testosterone Cause Depression?<\/h3>\n<p><a href=\"https:\/\/www.edrugstore.com\/blog\/wp-content\/uploads\/2022\/06\/unnamed-28.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-32950\" title=\"Medical Form with the words Low Testosterone\" src=\"https:\/\/www.edrugstore.com\/blog\/wp-content\/uploads\/2022\/06\/unnamed-28.jpg\" alt=\"Medical Form with the words Low Testosterone\" width=\"600\" height=\"400\" srcset=\"https:\/\/www.edrugstore.com\/blog\/wp-content\/uploads\/2022\/06\/unnamed-28.jpg 512w, https:\/\/www.edrugstore.com\/blog\/wp-content\/uploads\/2022\/06\/unnamed-28-300x200.jpg 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><\/a><\/p>\n<p><span style=\"font-weight: 400;\">People with low T commonly report anxiety, depression, and irritability. <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3992230\/#:~:text=It%20was%20concluded%20that%20men,lower%20with%20increased%20testosterone%20levels.\"><span style=\"font-weight: 400;\">Research<\/span><\/a><span style=\"font-weight: 400;\"> has shown a connection between total low testosterone levels and depressive symptoms in older men. However, additional research is needed to establish the exact link between depression symptoms and low T.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Since the symptoms of low T and depression overlap, it can be difficult to determine the exact cause of depressive symptoms without further testing.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">For example, both low T and depression can cause:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Anxiety<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Difficulty concentrating<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Irritability<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mood changes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Memory problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Reduced sex drive<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Trouble sleeping<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">However, the physical symptoms of low T and depression present differently. If you\u2019re experiencing depressive symptoms in addition to symptoms like muscle weakness, you may wish to test for low T. Depression symptoms not caused by low T are most likely to be accompanied by headaches and back pain.<\/span><\/p>\n<h3>Does Testosterone Replacement Therapy Improve Depressive Symptoms?<\/h3>\n<p><a href=\"https:\/\/www.edrugstore.com\/blog\/wp-content\/uploads\/2022\/06\/unnamed-27.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-32951\" title=\"Man talking to a therapist\" src=\"https:\/\/www.edrugstore.com\/blog\/wp-content\/uploads\/2022\/06\/unnamed-27.jpg\" alt=\"Man talking to a therapist\" width=\"600\" height=\"401\" srcset=\"https:\/\/www.edrugstore.com\/blog\/wp-content\/uploads\/2022\/06\/unnamed-27.jpg 512w, https:\/\/www.edrugstore.com\/blog\/wp-content\/uploads\/2022\/06\/unnamed-27-300x200.jpg 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><\/a><\/p>\n<p><span style=\"font-weight: 400;\">Though additional research is needed to confirm the exact connection between low T and depression, researchers have explored the use of testosterone replacement therapy (TRT) to treat depression. Your provider can help you determine if TRT is the right treatment option for your depression symptoms.\u00a0<\/span><\/p>\n<h4>What is Testosterone Replacement Therapy?<\/h4>\n<p><a href=\"https:\/\/www.urologyhealth.org\/healthy-living\/urologyhealth-extra\/magazine-archives\/summer-2017\/testosterone-replacement-therapy-is-it-right-for-you\"><span style=\"font-weight: 400;\">TRT<\/span><\/a><span style=\"font-weight: 400;\"> is currently approved to treat delayed male puberty, low testosterone production, and some inoperable breast cancers. It\u2019s offered as a topical gel, subdermal pellets, patches, and via injection. The most popular options tend to be topical gels and patches.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">TRT is not right for everyone and should be used exactly as directed under your provider\u2019s care. Your provider will continually monitor your testosterone levels throughout your treatment.\u00a0<\/span><\/p>\n<h4>What Does the Research Say About Testosterone Replacement Therapy?<\/h4>\n<p><span style=\"font-weight: 400;\">Researchers have found TRT to be a promising treatment for depression in men. Most research has specifically looked at using TRT in men with hypogonadism and other forms of androgen deficiency.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">A <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK77260\/\"><span style=\"font-weight: 400;\">systematic review and meta-analysis<\/span><\/a><span style=\"font-weight: 400;\"> found that TRT appeared to have an antidepressant effect on patients with hypogonadism or HIV infection. This review did have limitations and did not recommend applying the results to the general population. However, the researchers did recommend that providers evaluate testosterone levels in patients presenting with depression.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Another <\/span><a href=\"https:\/\/jamanetwork.com\/journals\/jamapsychiatry\/fullarticle\/2712976\"><span style=\"font-weight: 400;\">large meta-analysis<\/span><\/a><span style=\"font-weight: 400;\"> aimed to determine if TRT was effective in men without hypogonadism. The researchers examined 27 randomized placebo-controlled trials and found TRT to be more effective than placebo in reducing depression symptoms. These results were most significant in participants who received higher-dosage regimens.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">There are some conflicting research studies, however. For example, a <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3376477\/\"><span style=\"font-weight: 400;\">review<\/span><\/a><span style=\"font-weight: 400;\"> examining testosterone supplementation in older men with depression did not find enough evidence to confirm TRT as an effective treatment option. However, they did find testosterone supplementation to be significantly effective in improving several self-reported quality of life domains, such as sex drive and cognitive function.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Additional research is needed to determine the effectiveness of TRT in men with depression, regardless of their testosterone levels.<\/span><\/p>\n<h3>At-Home Testosterone Test Kits<\/h3>\n<p><span style=\"font-weight: 400;\">If you feel down, blue, or irritable, it may be due to low T. If you suspect low T may be contributing to your symptoms, you can now test your testosterone levels at home. These tests use your saliva to test your free testosterone levels.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Simply order our <\/span><a href=\"https:\/\/www.edrugstore.com\/test-kits\/testosterone-home-test-kit\/\"><span style=\"font-weight: 400;\">testosterone home test<\/span><\/a><span style=\"font-weight: 400;\"> to have it shipped to your door. Follow the easy-to-use instructions to collect and send off your sample. You will receive your results online in two to five days.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Consultations are always free, and if your results are positive, you will receive a free consultation to discuss next steps. <\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Highlights Testosterone plays an important role in your physical and mental health. Low testosterone (low T) is linked to mood changes like depression.\u00a0 Testosterone replacement therapy (TRT) has shown promise in treating depression in men with low T.\u00a0 TRT may not work for everyone, so it\u2019s best to speak with a provider about your treatment [&hellip;]<\/p>\n","protected":false},"author":13,"featured_media":32952,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_autoblog_aioseo_focus_keyphrase":"","_autoblog_aioseo_title":"","_autoblog_aioseo_description":"","footnotes":""},"categories":[1927],"tags":[],"class_list":["post-32949","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-testosterone"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO Pro 4.9.10 - aioseo.com -->\n\t<meta name=\"description\" content=\"Low testosterone is commonly linked to depression. Learn how testosterone impacts mood and how replacement therapy may help to improve your depression symptoms.\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<meta name=\"author\" content=\"Shelby Graves\"\/>\n\t<link rel=\"canonical\" href=\"https:\/\/www.edrugstore.com\/blog\/testosterone\/can-low-testosterone-cause-depression\/\" \/>\n\t<meta name=\"generator\" content=\"All in One SEO Pro (AIOSEO) 4.9.10\" \/>\n\t\t<meta property=\"og:locale\" content=\"en_US\" \/>\n\t\t<meta property=\"og:site_name\" content=\"Online Prescription Medications | eDrugstore Online Pharmacy Over 4 Million Prescriptions Lifestyle Medications\" \/>\n\t\t<meta property=\"og:type\" content=\"article\" \/>\n\t\t<meta property=\"og:title\" content=\"Can Low Testosterone Cause Depression? | Online Prescription Medications\" \/>\n\t\t<meta property=\"og:description\" content=\"Low testosterone is commonly linked to depression. 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