{"id":30144,"date":"2021-03-02T08:00:52","date_gmt":"2021-03-02T08:00:52","guid":{"rendered":"https:\/\/www.edrugstore.com\/blog\/?p=30144"},"modified":"2024-09-26T16:17:26","modified_gmt":"2024-09-26T09:17:26","slug":"best-drug-to-take-for-premature-ejaculation-treatment","status":"publish","type":"post","link":"https:\/\/www.edrugstore.com\/blog\/premature-ejaculation\/best-drug-to-take-for-premature-ejaculation-treatment\/","title":{"rendered":"What&#8217;s the Best Drug to Take for Premature Ejaculation Treatment?"},"content":{"rendered":"<p data-speechify-sentence=\"\"><strong>Overview:<\/strong> Doctors may consider prescribing medications &#8220;off-label&#8221; for premature ejaculation, including selective serotonin reuptake inhibitors (SSRIs), most notably paroxetine (Paxil.) However, there are potential risks to the approach, and it&#8217;s often best paired with ED medications and behavioral treatment options.<\/p>\n<h3>Is There Really A Drug For Premature Ejaculation?<\/h3>\n<p data-speechify-sentence=\"\">There is no drug specifically designed to treat PE that&#8217;s FDA-approved in the U.S. Instead, there are medications that are prescribed \u201coff-label\u201d to treat it. Technically speaking, an off-label use is one that&#8217;s <a href=\"https:\/\/www.fda.gov\/patients\/learn-about-expanded-access-and-other-treatment-options\/understanding-unapproved-use-approved-drugs-label\">not approved by government authorities.<\/a> It tends to exploit either a common side effect or primary effect of the medication in ways that haven&#8217;t been subject to the full range of study to be declared medically useful for that purpose.<\/p>\n<p data-speechify-sentence=\"\">In that context, there are multiple drugs that have a delay of orgasm as a common side effect and are similarly well-understood; thus, they might be used off-label to treat PE. They might even be drugs you&#8217;re considering taking for their primary purposes.<\/p>\n<h3>Which Is the Best Drug for PE?<\/h3>\n<p data-speechify-sentence=\"\">Two classes of drugs are most often prescribed for premature ejaculation: selective serotonin reuptake inhibitors (SSRIs, which are antidepressants) and phosphodiesterase-5 inhibitors (PDE5 inhibitors, as mentioned above).<\/p>\n<p><strong><img loading=\"lazy\" decoding=\"async\" class=\"fr-fil fr-dib aligncenter\" style=\"width: 900px;\" src=\"https:\/\/www.mediashower.com\/img\/8B3542BC-644E-11EB-BBE5-182CA0971845\/AdobeStock_258020270_900x.jpg\" alt=\"Pink tablets.\" width=\"900\" height=\"578\" \/><\/strong><\/p>\n<h3>SSRIs for Premature Ejaculation<\/h3>\n<p data-speechify-sentence=\"\">The most commonly used medication to treat PE is paroxetine, an SSRI sold under the name Paxil. Several studies (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31808410\/\">like this one<\/a>) have found SSRIs to be an effective treatment for PE because of their side effect of delaying ejaculation.<\/p>\n<h3>PDE5 Inhibitors<\/h3>\n<p data-speechify-sentence=\"\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7233005\/\">Research<\/a> shows that phosphodiesterase-5 inhibitors (PDE5 inhibitors) like <a href=\"https:\/\/www.edrugstore.com\/erectile-dysfunction\/sildenafil-citrate\/\">sildenafil<\/a> (better known as <a href=\"https:\/\/www.edrugstore.com\/blog\/premature-ejaculation\/best-drug-to-take-for-premature-ejaculation-treatment\/\">Viagra<\/a>) or <a href=\"https:\/\/www.edrugstore.com\/erectile-dysfunction\/tadalafil-tabs\/\">tadalafil<\/a> (aka <a href=\"https:\/\/www.edrugstore.com\/erectile-dysfunction\/cialis\/\">Cialis<\/a>) can treat PE symptoms in many men because of their mechanism of action.<\/p>\n<p data-speechify-sentence=\"\">These erectile dysfunction medications work by opening up the blood vessels of the penis to enable longer, firmer erections. However, since it&#8217;s taken orally, Viagra travels through and opens up blood vessels across the entire body, not just the penis. If you have a <a href=\"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCULATIONAHA.104.523324\">circulatory disorder,<\/a> for example, this may be useful regardless of whether you need Viagra in bed or not.<\/p>\n<p data-speechify-sentence=\"\">However, these drugs have on the market for decades, with well-understood side effects and risks, so doctors frequently prescribe them off-label for premature ejaculation.<\/p>\n<h3>SSRI Plus a PDE5 Inhibitor<\/h3>\n<p data-speechify-sentence=\"\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5503121\/#S21title\">Other studies<\/a> show that ED meds are more effective still when combined with an SSRI as part of a multi-pronged approach.<\/p>\n<p data-speechify-sentence=\"\"><strong>Is There a Downside to Off-Label Prescriptions?<\/strong><\/p>\n<p data-speechify-sentence=\"\"><span style=\"background-color: initial; font-size: 1em;\">There are reasons to be careful around off-label use, and it should only be done after discussing the issue thoroughly with your doctor. \u00a0For example, S<\/span><span style=\"background-color: initial; font-size: 1em;\">SRIs can have counterproductive side effects, like loss of libido or nausea, and paroxetine shouldn&#8217;t be taken by anyone on blood thinners, which include most over-the-counter analgesics like aspirin and ibuprofen.<\/span><\/p>\n<p data-speechify-sentence=\"\"><span style=\"background-color: initial; font-size: 1em;\">Another drug notable for delayed orgasm is Tramadol, an analgesic, but that medication has a high risk of becoming dependency-forming, a side effect most doctors would insist isn&#8217;t worth risking unless the patient is under severe emotional distress and has exhausted all other options.\u00a0<\/span><\/p>\n<p data-speechify-sentence=\"\">Beyond this, the trials mentioned above are all small ones. While the results are promising, larger-scale clinical trials would be necessary for a definitive answer. Secondly, <a href=\"https:\/\/bmcurol.biomedcentral.com\/articles\/10.1186\/s12894-018-0431-7\">an analysis of paroxetine and PE studies<\/a> found that the efficacy of paroxetine varies widely from experiment to experiment. While it seems to work well for some men, it is not a solution for everyone.<\/p>\n<h3>The Bottom Line<\/h3>\n<p data-speechify-sentence=\"\">The best approach to treatment is to work with your doctor and develop a multi-pronged approach. PE is a complicated and personal issue, and there&#8217;s no one pill or technique that best addresses it. Information is your best tool on the way to better sexual health, and working with your doctor can ensure that journey is a safe one.<\/p>\n<h3>How eDrugstore Can Help<\/h3>\n<p data-speechify-sentence=\"\">If you and your doctor decide that a PE med trial is a good option for you, please see our <a href=\"https:\/\/www.edrugstore.com\/erectile-dysfunction\/compare-viagra-cialis-levitra-staxyn-stendra-find-best-erection-medications\/ \">lifestyle medication guide<\/a> to learn more about PDE5 inhibitors, including Viagra, Cialis, <a href=\"https:\/\/www.edrugstore.com\/erectile-dysfunction\/vardenafil\/\">Levitra<\/a>, and more. We also offer a <a href=\"https:\/\/www.edrugstore.com\/pe-kit\/ \">premature ejaculation kit<\/a>, which may be a better option for some men.<\/p>\n<p data-speechify-sentence=\"\">If you would prefer to talk to one of our doctors about PE or <a class=\"ms_click_tracking\" href=\"https:\/\/www.edrugstore.com\/erectile-dysfunction\/?__mscta=2392_86455_35\">erectile dysfunction<\/a>, we offer a free medical consultation with a U.S.-licensed physician who can help you decide which PE treatment may be best for you. Simply call 1-800-467-5146 to get started.<\/p>\n<p><!-- Media Shower Impressions --><\/p>\n<div class=\"ms_article_id\" style=\"display: none;\" data-ms-article-id=\"86455\"><\/div>\n<p><!-- \/Media Shower Impressions --><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Overview: Doctors may consider prescribing medications &#8220;off-label&#8221; for premature ejaculation, including selective serotonin reuptake inhibitors (SSRIs), most notably paroxetine (Paxil.) However, there are potential risks to the approach, and it&#8217;s often best paired with ED medications and behavioral treatment options. Is There Really A Drug For Premature Ejaculation? There is no drug specifically designed to [&hellip;]<\/p>\n","protected":false},"author":15,"featured_media":30145,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_autoblog_aioseo_focus_keyphrase":"","_autoblog_aioseo_title":"","_autoblog_aioseo_description":"","footnotes":""},"categories":[1129],"tags":[],"class_list":["post-30144","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-premature-ejaculation"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO Pro 4.9.10 - aioseo.com -->\n\t<meta name=\"description\" content=\"Doctors may consider prescribing medications &quot;off-label&quot; for premature ejaculation, including selective serotonin reuptake inhibitors (SSRIs), most notably paroxetine (Paxil.)\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<meta name=\"author\" content=\"Dan Seitz\"\/>\n\t<link 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