{"id":20484,"date":"2022-02-23T09:18:34","date_gmt":"2022-02-23T02:18:34","guid":{"rendered":"https:\/\/www.accessrx.com\/blog\/?p=20484"},"modified":"2025-02-27T17:46:15","modified_gmt":"2025-02-27T10:46:15","slug":"will-i-develop-a-tolerance-to-viagra-long-term","status":"publish","type":"post","link":"https:\/\/www.edrugstore.com\/blog\/erectile-dysfunction\/viagra\/will-i-develop-a-tolerance-to-viagra-long-term\/","title":{"rendered":"Will I Develop a Tolerance to Viagra Long Term?"},"content":{"rendered":"<p><b>Highlights<\/b><\/p>\n<ul>\n<li aria-level=\"1\"><b>Can you build a tolerance to Viagra<\/b><b> long-term? The science says no.<\/b><\/li>\n<li aria-level=\"1\"><b>Some medications, like antibiotics, gradually lose their potency with long-term use.<\/b><\/li>\n<li aria-level=\"1\"><b>Viagra is not like other medications in that it seems to work as well in the long term as it does when first taken.\u00a0<\/b><\/li>\n<li aria-level=\"1\"><b>Users are unlikely to develop a tolerance to Viagra or other oral erectile dysfunction drugs.<\/b><\/li>\n<\/ul>\n<hr \/>\n<p><span style=\"font-weight: 400;\">Can you build a tolerance to Viagra? <\/span><span style=\"font-weight: 400;\">Probably not. It is true that some medications lose their potency over time, and some patients develop tolerance to them. This does not seem to be true for Viagra, the brand name of the drug sildenafil. Men taking Viagra or other medications for ED aren\u2019t likely to build up a tolerance.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Can you build a tolerance to Viagra?\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">If you\u2019ve been taking Viagra (sildenafil) for a long time, you may have wondered if it may eventually let you down as you build a tolerance to it. For most men, the news is good: when used as directed, Viagra retains its potency.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">While many medications lose their effectiveness over time and require larger doses, <a href=\"https:\/\/www.edrugstore.com\/erectile-dysfunction\/buy-viagra\/\">Viagra<\/a> is not one of them \u2014 if you\u2019re taking it as directed. That means no more than once in 24 hours and usually with a single tablet of 25, 50, or 100 milligrams, the lowest dose that will do the job.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">It\u2019s very unlikely that a man will build a tolerance to Viagra over time.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Here\u2019s What the Science Says<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">There were a few early studies that suggested that men could build a tolerance to sildenafil. But that research has mostly been discredited, and there\u2019s far more clinical evidence that tolerance is rare.<\/span><\/p>\n<h4><span style=\"font-weight: 400;\">The Yeas \u2013 Weak Evidence<\/span><\/h4>\n<p><span style=\"font-weight: 400;\">These are early studies whose results are questioned.<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">A case <\/span><a href=\"http:\/\/www.indianjpsychiatry.org\/article.asp?issn=0019-5545;year=2015;volume=57;issue=3;spage=311;epage=312;aulast=Sathyanarayana#ref6\"><span style=\"font-weight: 400;\">study<\/span><\/a><span style=\"font-weight: 400;\"> describes one patient who needed to keep increasing his sildenafil for more than ten years of worsening ED. He was ultimately taking an ultra-high dose. However, the study\u2019s author pointed out that a full medical history wasn\u2019t taken on this patient. He may have had an underlying disease (in addition to aging) that caused the worsening ED. Also, the experience of one patient isn\u2019t enough for a reliable conclusion.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">In a 2001 <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11490248\/\"><span style=\"font-weight: 400;\">trial<\/span><\/a><span style=\"font-weight: 400;\">, the authors followed a small group of patients for two years. In that time, 17% stopped taking the sildenafil because it stopped working, and 20% had to increase the dose to have the same effect. The study concluded that there is a possible tolerance effect to sildenafil. In the year following, however, the authors of another <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1476025\/\"><span style=\"font-weight: 400;\">study<\/span><\/a><span style=\"font-weight: 400;\"> suggested that there were design issues with that 2001 trial. There were too few participants, many of them didn\u2019t show up for follow-up (54%), and the methods used were of low quality.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">To date, there is no good-quality research that suggests that Viagra (or any of the PDE5 inhibitors \u2014 including <\/span><a href=\"https:\/\/www.edrugstore.com\/erectile-dysfunction\/cialis\/\"><span style=\"font-weight: 400;\">Cialis<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.edrugstore.com\/erectile-dysfunction\/vardenafil\/\"><span style=\"font-weight: 400;\">Levitra<\/span><\/a><span style=\"font-weight: 400;\"> \u2014 can lead to tachyphylaxis (the fancy name for tolerance buildup).<\/span><\/p>\n<h4><span style=\"font-weight: 400;\">The Nays \u2013 Stronger Evidence<\/span><\/h4>\n<p><span style=\"font-weight: 400;\">These are just a few examples of studies showing little to no evidence of sildenafil tachyphylaxis:<\/span><\/p>\n\n<table id=\"tablepress-68\" class=\"tablepress tablepress-id-68\">\n<thead>\n<tr class=\"row-1\">\n\t<th class=\"column-1\">Year of Study<\/th><th class=\"column-2\">Number of Participants<\/th><th class=\"column-3\">Length of Study<\/th><th class=\"column-4\">Results<\/th>\n<\/tr>\n<\/thead>\n<tbody class=\"row-striping\">\n<tr class=\"row-2\">\n\t<td class=\"column-1\">2003<\/td><td class=\"column-2\">360<\/td><td class=\"column-3\">4 years<\/td><td class=\"column-4\">96% satisfied<\/td>\n<\/tr>\n<tr class=\"row-3\">\n\t<td class=\"column-1\">2003<\/td><td class=\"column-2\"><\/td><td class=\"column-3\">3 years<\/td><td class=\"column-4\">71% satisfied<\/td>\n<\/tr>\n<tr class=\"row-4\">\n\t<td class=\"column-1\">2007<\/td><td class=\"column-2\">979<\/td><td class=\"column-3\">4 years<\/td><td class=\"column-4\">94% satisfied<\/td>\n<\/tr>\n<tr class=\"row-5\">\n\t<td class=\"column-1\">2010 review of 67 trials<\/td><td class=\"column-2\">13,000+<\/td><td class=\"column-3\">7 years of data<\/td><td class=\"column-4\">no evidence of tolerance<\/td>\n<\/tr>\n<tr class=\"row-6\">\n\t<td class=\"column-1\">Postmarketing reports*<\/td><td class=\"column-2\">39,277<\/td><td class=\"column-3\">Not reported<\/td><td class=\"column-4\">58 (0.15%) reported dependence<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<!-- #tablepress-68 from cache -->\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">A 2003 study of men taking Viagra for ED caused by prostate cancer treatment with radiation. The study followed 360 men for four years and found that 96% of them reported that the drug was still as effective as it had been at first, according to <\/span><a href=\"https:\/\/www.webmd.com\/erectile-dysfunction\/news\/20031021\/viagra-works-for-long-haul#1\"><span style=\"font-weight: 400;\">WebMD<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Another 2003 study found that 71% of men were still satisfied with their dosages of Viagra in a three-year follow-up.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">In a similar <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2387281\/\"><span style=\"font-weight: 400;\">study<\/span><\/a><span style=\"font-weight: 400;\"> published in 2007, 979 participants were followed for four years to assess the safety and effectiveness of flexible-dose (50 or 100 milligrams used as needed) sildenafil. They were interviewed once a year. At the end of the four years, more than 94% of participants were still happy with their erections and satisfied with their sex lives. As shown in the chart below, that percentage included 189 men who took a total of 451 to 550 doses in the four years covered by the study. Even the 13 men who took up to 1300 doses reported little or no tachyphylaxis in that time.<\/span><\/li>\n<\/ul>\n<p><a href=\"https:\/\/www.edrugstore.com\/blog\/wp-content\/uploads\/2020\/09\/2_11zon.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-32001 size-full\" title=\"Chart showing recommended dosages for men's ED medications\" src=\"https:\/\/www.edrugstore.com\/blog\/wp-content\/uploads\/2020\/09\/2_11zon.png\" alt=\"Men's Dosage Chart\" width=\"600\" height=\"400\" srcset=\"https:\/\/www.edrugstore.com\/blog\/wp-content\/uploads\/2020\/09\/2_11zon.png 600w, https:\/\/www.edrugstore.com\/blog\/wp-content\/uploads\/2020\/09\/2_11zon-300x200.png 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><\/a><\/p>\n<p><i><span style=\"font-weight: 400;\">Usage of flexible-dose (25, 50, and 100 mg) sildenafil over 2\u20131561 days by the 979 participants who entered the study. 94% of these men said that they were satisfied with their erections and their sexual activity after four years of use. (<\/span><\/i><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2387281\/\"><i><span style=\"font-weight: 400;\">Source<\/span><\/i><\/a><i><span style=\"font-weight: 400;\">)<\/span><\/i><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">But What If I Don\u2019t Use Viagra as Directed?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">If you\u2019re using Viagra recreationally (meaning you don\u2019t have ED but use it to prolong your erections or to have more than one in a session), then you may be at risk for building a tolerance. However, this is more likely to be a <\/span><a href=\"https:\/\/www.edrugstore.com\/blog\/erectile-dysfunction\/viagra\/is-it-possible-to-be-addicted-to-viagra\/\"><span style=\"font-weight: 400;\">psychological issue <\/span><\/a><span style=\"font-weight: 400;\">than a physical one.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Overall, there is about a <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2810448\/#:~:text=In%20addition%2C%20there%20is%20no,over%204%20years%20(75).\"><span style=\"font-weight: 400;\">0.15%<\/span><\/a><span style=\"font-weight: 400;\"> chance of developing a dependency on Viagra. Almost always, the dependence is psychological and due to misuse or abuse.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If you don\u2019t have ED but use sildenafil as a regular part of your sex life, you may be training your mind to believe it needs Viagra to achieve an erection. In this case, Viagra may cause impotence rather than treat it. It\u2019s probably not a risk worth taking for most guys.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Why Has Viagra Stopped Working for Me?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">There are <\/span><a href=\"https:\/\/www.edrugstore.com\/blog\/erectile-dysfunction\/viagra\/sometimes-viagra-doesnt-work-what-does-this-mean\/\"><span style=\"font-weight: 400;\">many reasons <\/span><\/a><span style=\"font-weight: 400;\">for a man to have weaker effects from Viagra than he did in the beginning. Here are just a few:<\/span><b><\/b><\/p>\n<ul>\n<li><b>You didn\u2019t follow the manufacturer\u2019s instructions. <\/b><span style=\"font-weight: 400;\">It\u2019s essential to take Viagra just as directed.<\/span><\/li>\n<li><b>You didn\u2019t allow enough time for it to work. <\/b><span style=\"font-weight: 400;\">Viagra enters the system and starts working after about an hour.<\/span><\/li>\n<li><b>You took too much. <\/b><span style=\"font-weight: 400;\">Again, you should only take the recommended dose.<\/span><\/li>\n<li><b>You used it after a heavy, high-fat meal. <\/b><span style=\"font-weight: 400;\">Eating a high-fat meal can slow your body\u2019s ability to absorb Viagra.<\/span>\n<ul>\n<li><b>You\u2019ve had too much to drink.<\/b> <a href=\"https:\/\/www.edrugstore.com\/blog\/erectile-dysfunction\/viagra\/your-quick-guide-to-viagra-alcohol-and-ed\/\"><span style=\"font-weight: 400;\">Alcohol<\/span><\/a><span style=\"font-weight: 400;\"> is not an erection\u2019s BFF.<\/span><\/li>\n<li><b>You drank a Red Bull or two.<\/b> <a href=\"https:\/\/www.edrugstore.com\/blog\/erectile-dysfunction\/viagra\/caffeine-vodka-red-bull-and-viagra\/#\"><span style=\"font-weight: 400;\">Caffeine <\/span><\/a><span style=\"font-weight: 400;\">is also not erection-friendly.<\/span><\/li>\n<\/ul>\n<\/li>\n<li><b>You may have been tired or too stressed. <\/b><span style=\"font-weight: 400;\">Erections need you to be able to relax and let it happen.<\/span><\/li>\n<li><b>You may be taking a <\/b><a href=\"https:\/\/www.edrugstore.com\/blog\/erectile-dysfunction\/which-blood-pressure-medications-dont-cause-erectile-dysfunction\/\"><b>medication that can interfere<\/b><\/a><b> with Viagra\u2019s effects.\u00a0<\/b><\/li>\n<li><b>You may have a health condition (like <\/b><a href=\"https:\/\/care.diabetesjournals.org\/content\/25\/12\/2159\"><b>diabetes<\/b><\/a><b>) that would make a different PDE5 inhibitor a better choice for you. <\/b><span style=\"font-weight: 400;\">(Diabetics may want to give Cialis a try.)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">If you continue to have unsatisfactory experiences with your Viagra, check out <\/span><a href=\"https:\/\/www.edrugstore.com\/blog\/erectile-dysfunction\/viagra\/when-viagra-doesnt-work\/\"><span style=\"font-weight: 400;\">our article<\/span><\/a><span style=\"font-weight: 400;\"> about things you can try to improve how Viagra works for you. If all else fails, talk to your doctor about switching medications.\u00a0 Not all men react the same way to ED medications.<\/span><\/p>\n<p><a href=\"https:\/\/www.edrugstore.com\/blog\/wp-content\/uploads\/2020\/09\/3.jpeg-2_11zon.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-32002 size-full\" title=\"Older couple hugging on the beach\" src=\"https:\/\/www.edrugstore.com\/blog\/wp-content\/uploads\/2020\/09\/3.jpeg-2_11zon.jpg\" alt=\"Older couple hugging on the beach\" width=\"600\" height=\"400\" srcset=\"https:\/\/www.edrugstore.com\/blog\/wp-content\/uploads\/2020\/09\/3.jpeg-2_11zon.jpg 600w, https:\/\/www.edrugstore.com\/blog\/wp-content\/uploads\/2020\/09\/3.jpeg-2_11zon-300x200.jpg 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><\/a><\/p>\n<h3><span style=\"font-weight: 400;\">The Bottom Line<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">The most reliable studies say that it\u2019s unlikely you can develop a Viagra or sildenafil tolerance. If you follow your doctor\u2019s advice and learn about the factors that could be affecting your response, you and Viagra should have a long and satisfying relationship.\u00a0\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If you are interested in trying Viagra or considering another <\/span><a href=\"https:\/\/www.edrugstore.com\/erectile-dysfunction\/\"><span style=\"font-weight: 400;\">ED medication<\/span><\/a><span style=\"font-weight: 400;\">, we have what you need. Take advantage of our discreet online ordering process and free medical evaluation to get started on a more satisfying love life today.<\/span><\/p>\n<p><!-- Media Shower Impressions --><\/p>\n<div class=\"ms_article_id\" style=\"display: none;\" data-ms-article-id=\"70805\"><\/div>\n<p><!-- \/Media Shower Impressions --><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Highlights Can you build a tolerance to Viagra long-term? The science says no. Some medications, like antibiotics, gradually lose their potency with long-term use. Viagra is not like other medications in that it seems to work as well in the long term as it does when first taken.\u00a0 Users are unlikely to develop a tolerance [&hellip;]<\/p>\n","protected":false},"author":18,"featured_media":29545,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_autoblog_aioseo_focus_keyphrase":"","_autoblog_aioseo_title":"","_autoblog_aioseo_description":"","footnotes":""},"categories":[20,17],"tags":[184],"class_list":["post-20484","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-erectile-dysfunction","category-viagra","tag-viagra"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO Pro 4.9.10 - aioseo.com -->\n\t<meta name=\"description\" content=\"Can you build a tolerance to Viagra over time? 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