Man sitting down.

Your Top 10 Questions About Peyronie’s Disease Answered

Overview: Peyronie’s disease is caused by scar tissue that collects on the penis, potentially causing bends and painful erections. It isn’t dangerous, but it may interfere with intimacy and usually won’t go away without treatment.

1. What is Peyronie’s disease?

Peyronie’s disease is the growth of scar tissue in the tunica albuginea, a thick sheaf of connective tissue which surrounds the corpora cavernosa. The cavernosa are two tubes of sponge-like tissue that fill with blood when a man gets an erection, and the connective tissue protects it from injury. The tunica also provides shape to the penis and helps maintain an erection by constricting the veins in the penis, preventing blood from flowing out as quickly as it comes in.

2. What causes Peyronie’s disease? 

What causes Peyronie’s is currently not clear. It’s believed that repeated mild trauma to the penis due to certain types of sex or exercise can build up scar tissue over time, yet debate remains. Often sufferers can’t remember any specific injury. Peyronie’s also shouldn’t be confused with penile fracture, an extremely rare accident where the sheath surrounding the erectile cylinders is ruptured by some form of injury while a man has an erection.

3. How common is Peyronie’s disease?

Peyronie’s affects about 10% of men, and it becomes more common as men age. That said, cases have been found in very young men, although the reasons it might happen that young are not clear.

4. Is Peyronie’s disease dangerous?

Peyronie’s is not life-threatening or a symptom of a more serious disease involving the penis. It also can’t be communicated to a partner. That said, Peyronie’s disease can cause painful erections and change the shape of the penis, including shortening or loss of girth. Due to changes in blood flow, erections may be less firm. The pain can make it difficult to maintain an erection and enjoy sex and may contribute to erectile dysfunction.

Men with Peyronie’s disease also have a higher risk of developing prostate issues such as benign prostatic hypertrophy, lower urinary tract symptoms, and cancer.

In addition, sufferers can experience anxiety and other mental health symptoms. While images of Peyronie’s found online are usually extreme cases, unsurprisingly, many men find it dismaying that their penis is bending or distorting. So while not fatal, Peyronie’s disease directly impacts the quality of life and the health of intimate relationships.

Man sitting at the edge of his bed.5. Is Peyronie’s disease hereditary?

It can be. Researchers believe that there may be a genetic predisposition to Peyronie’s, particularly among men of European descent.

6. What are the risk factors of Peyronie’s disease?

In addition to genetics, there are other risk factors for Peyronie’s, including:

  • Diabetes
  • Smoking
  • Heavy alcohol consumption
  • Connective tissue diseases like Dupuytren’s contracture (where the fingers curve towards the palm and the hand can’t be fully opened) or plantar fibromatosis (a benign nodule on the sole of the foot)
  • Injury or other trauma to the penis

If you’re already working with a doctor on treating erectile dysfunction, you’ll notice there’s some overlap on this list with conditions that may impact ED as well. In fact, 80% of males ages 40 to 70 who have Peyronie’s also have erectile dysfunction.

7. What are the symptoms of Peyronie’s disease?

To diagnose Peyronie’s, look for the following symptoms:

  • Flat lumps or bands of hard tissue in the penis, especially when flaccid. This is scar tissue.
  • Pain, particularly when getting an erection, although pain may be present while not erect depending on where the scar tissue is located.
  • Erectile dysfunction, either newly presenting or worsening from a previous condition.
  • Changes to the penis, such as curves, dents, or indentations. These will begin appearing over time.

One important caveat: If you’ve had a curve in your penis since birth and experience no pain or other symptoms, that’s likely congenital curvature, which is no cause for alarm. It also isn’t a risk factor for Peyronie’s.

8. How can I prevent Peyronie’s disease?

Man lying down appearing sad.If you have a genetic predisposition to Peyronie’s, or to connective tissue diseases in general, the first step is to address related conditions. Quitting smoking, reducing your alcohol consumption to doctor-recommended levels or abstaining altogether, and proper diet and exercise to reduce the risk of diabetes will assist in reducing your chances of getting Peyronie’s.

During exercise or sports, wear a protective cup or similar protection to avoid trauma to the penis. In some cases, such as cycling, you may need to switch to a different style, such as a recumbent bike.

To avoid minor injury during sex, use lubricant where needed, and guide your penis where necessary. Remember also that certain positions require a different approach; if your partner is on top, for example, they should be aware of how they’re placing their weight and use a rocking motion as opposed to an up-and-down one, or let you thrust instead.

9. Is Peyronie’s disease permanent?

Some symptoms of Peyronie’s are, thankfully, not permanent. Usually, the progression stops between three and twelve months. The pain involved can fade after one to two years, depending on severity. In some cases, the changes to the penis will also eventually improve.

While Peyronie’s disease is treatable, unfortunately, in many cases, penis changes caused by Peyronie’s are permanent to at least some degree.

Man speaking with a medical doctor.

10. What is the treatment for Peyronie’s disease?

First, speak to a doctor about the situation and have them examine you. As we age, our bodies change, and that includes the penis.

Then, discuss treatment options. These include:

  • Injections. The enzyme collagenase Clostridium histolyticum is the most common medical intervention, marketed commercially as Xiaflex in the U.S. and Xiapex in the E.U. It’s an enzyme that breaks down collagen, generally injected at the site. There are currently no known drug interactions, although there are side effects, including swollen lymph nodes, itching, edema, and pain.
  • Penile traction therapy. PTT is a non-surgical treatment that uses a device to essentially bend the penis back into shape. However, this can be uncomfortable and awkward for the patient while going about daily life and needs a lot of dedication.
  • Surgery.  Finally, there is a surgical option, called the Nesbit operation. The penis is filled with salt water to form an artificial erection. Then, the excess tissue is removed at the curve, and stitches are used to straighten the penis. Since Peyronie’s isn’t life-threatening, and all surgery has a degree of risk, the Nesbit operation is generally only performed in extreme situations.

You don’t have to let your health impact your sex life. Learn more about sexual function, including erectile dysfunction, premature ejaculation, and other reproductive health issues, by visiting the eDrugstore blog.

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