Woman injecting herself.

Reviews for New ‘Female Viagra’ Vyleesi Not Great

Vyleesi offers an as-needed alternative to Addyi, a drug that must be taken daily to combat hypoactive sexual desire disorder in premenopausal women. Advance reviews are not all that promising. 

The advance buzz for Vyleesi, the latest form of “female Viagra” to hit the market, isn’t very promising. The injectable, scheduled to debut in September 2019, is designed to treat hypoactive sexual desire disorder, the most common form of female sexual dysfunction.

Vyleesi is the second such drug to win approval from the U.S. Food and Drug Administration. The first, Addyi, went on sale in October 2015. However, despite a very vocal campaign to get that drug approved, its performance has been less than spectacular.

‘Female Viagra’ Misleading

While both Addyi and Vyleesi have been called “female Viagra,” that label is misleading. Neither of these drugs works like the male erectile dysfunction medications, which are designed to improve blood flow to the penis, thus enabling impotent men to get and keep an erection, at least temporarily.

By contrast, Vyleesi and Addyi target brain chemistry as the best pathway toward increased sexual desire in premenopausal women. The new entrant is an injectable that’s used on an as-needed basis, while Addyi comes in tablet form and must be taken daily to deliver its promised results.

Results of Clinical Trials

Clinical trials of both medications have shown marginal improvements in sexual desire among female study participants. However, the relatively high cost of both these drugs and the lack of widespread insurance coverage combine to dampen demand.

In the case of Vyleesi, only about 25 percent of women participating in clinical trials had some increase in sexual desire, according to a report posted at WXYZ.com. The report also noted that 40 percent of the women participating in the trial experienced nausea after taking the drug.

According to PhysiciansWeekly.com, the price tag for a four-pack of Vyleesi auto-injectors will be $899. Injections should be made in the abdomen or thigh roughly 45 minutes before the anticipated start of sexual activity.

Addyi Must Be Taken Daily

By contrast, Addyi is a daily medication that must be taken every day for a few weeks before its full effects are felt. When it was first rolled out, Addyi came with a strict warning to avoid all alcohol use while taking the drug, which effectively rendered Addyi users teetotalers since it’s a daily medication.

For ladies who enjoy a glass or wine now and then just to relax, this made the use of Addyi virtually impossible. The no-alcohol warning has since been relaxed, although Addyi users are still warned to be cautious and moderate in their alcohol use while on the drug.

Vyleesi, Addyi Tweak Brain Chemistry

As previously noted, Vyleesi and Addyi differ from the male ED medications in that they focus on tweaking brain chemistry to increase female sexual desire. Bremelanotide, the active ingredient in Vyleesi, activates internal pathways in the brain that are related to sexual response, according to Palatin Technologies, which developed the drug. Palatin has licensed AMAG Pharmaceuticals to market Vyleesi in North America.

Flibanserin, the active ingredient in Addyi, is said to decrease brain levels of serotonin, a neurotransmitter known to inhibit sexual desire, while increasing levels of dopamine and norepinephrine, which increase sexual desire.

How the market will respond to Vyleesi remains to be seen. Its as-needed design could conceivably propel Vyleesi demand ahead of that for Addyi, which must be taken on a daily basis.

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For men who are suffering from vascular-related ED, Viagra and the other oral drugs known as PDE5 inhibitors should be able to help. And ordering drugs online from eDrugstore.com can often save you both time and money. To learn more about eDrugstore and its added-value services, pay a visit to its Erectile Dysfunction page.

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